ID   UTP25_CLAL4             Reviewed;         693 AA.
AC   C4XWY8;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=CLUG_00461;
OS   Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Metschnikowiaceae; Clavispora.
OX   NCBI_TaxID=306902;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42720;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CH408076; EEQ36337.1; -; Genomic_DNA.
DR   RefSeq; XP_002619301.1; XM_002619255.1.
DR   AlphaFoldDB; C4XWY8; -.
DR   STRING; 306902.C4XWY8; -.
DR   PRIDE; C4XWY8; -.
DR   EnsemblFungi; EEQ36337; EEQ36337; CLUG_00461.
DR   GeneID; 8499656; -.
DR   KEGG; clu:CLUG_00461; -.
DR   VEuPathDB; FungiDB:CLUG_00461; -.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; C4XWY8; -.
DR   OMA; KYFRQTI; -.
DR   Proteomes; UP000007703; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..693
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408113"
FT   REGION          1..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          273..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..103
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..132
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   693 AA;  78530 MW;  6E43ADFB53DB1FF9 CRC64;
     MKRPGSNKRP AKSKDGAESR PKRANRGRQQ LRTITRTARR DVDAPVEETP ESSESEAEEA
     APEEKKFEQG KAYDALLTLL QSEHPEKSDK KKTASRHEED DVAGVNLEED DDDDDEEEEE
     EENDEVEDDA NEHGDPFEVH FGVDDEAVAA KAALLSARWP VAHKAKVGAY AVTTHASPGE
     KTAACEAPRA QTLGAPVKKR VADAFAARHP APFSPLEQEL AHHIFSYRDV LYASRTYDNT
     VHRKLYAAHV LNHVFKTRDR VLKNNDVLKN YHSAQQQGKA TGPEPEPRDQ GFTRPKVLIL
     LPTRNAAYEV VEQLIGMSGA AQQENRRRFK AQFHADGGPP DSKPADFRAM FHGNSNDFFS
     IGLKFTRKSV KLYASFYGAD ILVASPIGLA MILEDPKQAK REYDFLSSIE VLVVDRANEL
     EMQNWDHVHT VLRYINKIPK DFHGADFSRI RMWAINDHAR LLRQTLVFCD FLTPSVSNVI
     THSQNIAGKT RFRPETTAQT CVMNSVGLRL KQIFQRFDAP DPQSSVDARF RFFVNSVLPS
     LSKQTSYDDG LLIYVPSYFD YVRLKAHMKT HTKLDFSAID EYSSRAKITR ARHFFSTGKT
     KLLLYTERLH HYRRFELAGV KNIVLYGPPE NPLFYKELLR FVGKSVFKGD ADTDLSFIKT
     IYCKWDAAAL ERICGAEKAA VLCNSVNEMF EFR