ID   UTP25_COCP7             Reviewed;         717 AA.
AC   C5P5Z4;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=CPC735_034700;
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; ACFW01000025; EER28134.1; -; Genomic_DNA.
DR   RefSeq; XP_003070279.1; XM_003070233.1.
DR   AlphaFoldDB; C5P5Z4; -.
DR   EnsemblFungi; EER28134; EER28134; CPC735_034700.
DR   GeneID; 9695774; -.
DR   KEGG; cpw:CPC735_034700; -.
DR   VEuPathDB; FungiDB:CPC735_034700; -.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Ribonucleoprotein; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..717
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408114"
FT   REGION          1..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..126
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..148
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  81160 MW;  FDD128E0B1D9907A CRC64;
     MAVKGAHARR GPPRRKLPKF ETSRVQDLDQ DNSPSEGPDA FDNESLDEAS DAEYSVVSSD
     SAEEERLTAK PYNALLQLLN VGADPNGPAR KKRKLKHKNK DNGKEDQVDK VKRSIPREVD
     SELQDDLDVK EASDDESESG DENDGIDEAD RDAAAGSDPF EAHFSQPDEA RLSKRIEAST
     KTWQTSKHQL SSGMRITATY PYAGNEQSLA LPPLHSLKDL PLKRKLSETA SEHMSQINAQ
     NSSIAPYIFG YYDMLYGART TENAASLRDM YCLHALNHII KTRDRVVKNN SRVPKEGEDV
     EMRDQGFTRP KVLILLPTRQ ACVRVVDSIS KFYRADQQEN KKRFLETFSE TDDKSWEDKP
     EDFQELFGGN DDDMFRLGLK FTRKTMKYFT QFYNSDIILA SPLGLRTAME KEDGKKQEYD
     FLSSIELVVV DHADALLMQN WDHVEYVFSH LNLQPKAAHG CDFSRVRTWY LDGNAKYLRQ
     TLIFTSFMSP EINSVYSTYA QNVSGKVKIN TTYQGAILDL PVPVPVKQTF SRFDSLSPVK
     DPETRFKYFT NTVLSSLAKN WSGSGKSSAS GTLIFIPSYL DFVRIRNYLA TSSQTTNLSF
     GAISEYTSVR DVARARSYFM NGRHSVLLYT ERLHHFRRYK IRGVKRVIMY GVPDNPLFYG
     EIVAFLGLDP SAVGEAAEKG VRALFSKWDA LKLERVVGTK RIGSMMMEKG GDTFTFT