ID   UTP25_DEBHA             Reviewed;         719 AA.
AC   Q6BYC4;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; OrderedLocusNames=DEHA2A10626g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CR382133; CAG84764.2; -; Genomic_DNA.
DR   RefSeq; XP_456795.2; XM_456795.1.
DR   AlphaFoldDB; Q6BYC4; -.
DR   STRING; 4959.XP_456795.2; -.
DR   EnsemblFungi; CAG84764; CAG84764; DEHA2A10626g.
DR   GeneID; 2899564; -.
DR   KEGG; dha:DEHA2A10626g; -.
DR   VEuPathDB; FungiDB:DEHA2A10626g; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; Q6BYC4; -.
DR   OMA; LYTERWH; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000000599; Chromosome A.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..719
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408116"
FT   REGION          1..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..75
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..113
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..154
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   719 AA;  83586 MW;  513B2F080A1BB1F7 CRC64;
     MPAPYKRKKH SGKRPEDSHD AKRPKQKHGR QEMRTITRTA RRVRRDEEGE EDEQVEENVN
     EELESQDDDI EDGGDIDDDK GKAYDALLTL LSGDHQEDTK KNTSVRAEPE QTQESESESD
     EDSGDDEIAG ANVDDDKDVD EEGPEEDDGD DDQQDPFEVH FNQVSDTFIE EQEKVLKDKP
     KWTFADKKSM EDAGYTYTFQ VPPNPIKTGG KVKGQSVNNY SIKQRLVSPF EKQHPESLNE
     LEGVLLDSMV KYQDINYVYK TFDNESYKKL YVLHALNHIF KTRDRILKNN NKLHSYQESM
     KKGKTNIEEP ELRDQGFTRP KVLILLPTRN ACYEIVELLI KLCGSEQQEN RKKFNKQFSS
     KETPPDSKPE DFKHSFKGNN NDFFCIGVKF TRKSLKLYSS FYSSDIIIAS PIGLSMILEN
     PDKKKRQYDF LSSIEVLVVD RANQIEMQNW DHVNTVFKYL NKIPKDFHDA DFSRIRMWSI
     NDQANLLRQN LVFSEFSTPN INNIVSSKSS NLSGKLRFKP VTTSKNCIMN SIGLKLKQIF
     QRFESNSPMT DPESRFKFFI NSVLPSLTRS TSYDDGLLIF IPSYYDYLRI KNYMKTSTKF
     TFASIDEYTS QSKLSRNRQQ FASGKIKIML YTERLHHFRR FEINGVKNLL MYGLPSNPIF
     YKELVRFIGK SVFREIADLD LSFIKILYSK WDAVALERIV GNERAPVLCN SVNEMYEFR