ID   UTP25_KLULA             Reviewed;         704 AA.
AC   Q6CP18;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; OrderedLocusNames=KLLA0E08229g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99408.1; -; Genomic_DNA.
DR   RefSeq; XP_454321.1; XM_454321.1.
DR   AlphaFoldDB; Q6CP18; -.
DR   STRING; 28985.XP_454321.1; -.
DR   PRIDE; Q6CP18; -.
DR   EnsemblFungi; CAG99408; CAG99408; KLLA0_E08229g.
DR   GeneID; 2894532; -.
DR   KEGG; kla:KLLA0_E08229g; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; Q6CP18; -.
DR   OMA; KYFRQTI; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0019843; F:rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..704
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408118"
FT   REGION          1..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..147
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   704 AA;  81864 MW;  C01437025D41F136 CRC64;
     MSKIRAGPKS GRKQLREITR AGQKRVRYDD EATVADLTPD NESDSDNAEP SVAAEREDVE
     QHRGQAYNAL LTLLKSEHPE RKHKSNKKIK KDSQRAEEDS PENDGINSED EQQNIENALD
     DVSGGVVDEE DMEDSLSDVD ESEDESDPFE SHFSKYSESR LYAFDKGFKD KTVKYKSSKT
     DVSEEESLIY SKPCLDDEEV LPVKGKQTLS SYFIKQKLKL ANDFQNNGLP LTEIQKELVD
     PMFQYKDMLY EYDDYADEDQ YRDLYSLHAL NHVYKTRDRI LKNNQKLQEN NDEELLDQGF
     TRPKVLIVVP TRDAAHKIVR KIMEKSGLDQ FDKKSKFEDQ FFEDSLPPTS KPKSFQHIFQ
     GNTNDFFVLG LKFTRKSLKI YSNFYQSDII ICSPLGIQLI LENTDKKKRQ DDFLSSIEVM
     IIDQLHSIEY QNAMHVTTIF QHINKIPEQQ READFSRIRM WYINEQAKFF RQTIVFTKYI
     SPFANSILNG KCRNLAGRWK NHRKIKPEQS SIGQLGLKVR QIFQRFDLAG GTALDEPDYR
     FKFFTSVIVP SIVKSTGYED GILLYIPDYT DFIRVRNYLK EKTTIIFGEI NEYSNQKQLT
     SNRARFQHGK VKVLLYTERL HHFRRYEIKN VKSVIFYKPP GNPEFYSEVV RNIGKNVFLG
     NCDINISTVR CIYSKMDGLS LERVVGSKRA AVLAHGQNEV YEFK