ID   UTP25_KOMPG             Reviewed;         697 AA.
AC   C4R2K0;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; OrderedLocusNames=PAS_chr2-2_0196;
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864;
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; FN392320; CAY69724.1; -; Genomic_DNA.
DR   RefSeq; XP_002492004.1; XM_002491959.1.
DR   AlphaFoldDB; C4R2K0; -.
DR   STRING; 644223.C4R2K0; -.
DR   PRIDE; C4R2K0; -.
DR   EnsemblFungi; CAY69724; CAY69724; PAS_chr2-2_0196.
DR   GeneID; 8198771; -.
DR   KEGG; ppa:PAS_chr2-2_0196; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; C4R2K0; -.
DR   OMA; LYTERWH; -.
DR   Proteomes; UP000000314; Chromosome 2.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..697
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408133"
FT   REGION          1..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..70
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..108
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..128
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   697 AA;  82513 MW;  846AAC5FE7A065FC CRC64;
     MTEANSNRNR SKHARSHYGR EELRTVRSVK RRTGGKNNYS KFTPMDNNES IVEESEDEGE
     EEDDEQEDPQ PSSMAYDALL TLLDDESDHE QFHAEKEKAL KKLEEEQERE EEELQEEDED
     EDEEDEEINL EDFESDDESH DDPFHFHFNE EESIDRMINE YESSGLKVKM DRKVNHNGYN
     ILEYLPSTSR CLNEVKTLDK LRIKKKLRDQ FSSLDFKDEL DKKLTLDIFN YKNINYQYYT
     RETDYQSLYL LHALNHLLKT RDRIFDHNNK ISADPNLEFK DQGYTRPKIL ILLPTRNFCF
     NLMNKLIKLA DIKTVENKKR FNTQFYSDFK IETLNGNKPK DFNEFFRGNS SDFFTLGVKF
     TRKSMKIYSM LKQSDIIFAS PLGLKMLLDK EKNDYLSSIE VTILDKADGL LMQNWDHVKQ
     IFTKSLIQAP KNFEELNCDF SRIRMWCIND QAKYVHQVLS FSKYTTPELN NIVKAPNLQG
     YALYKPIIDD TNNVMNQLNY QLFQSRIINK NIRLNHMFMR FPSSSPMESP KKRLNFFTKV
     ILPNVLTKSP YTSGTLVYIS SYLDYIQVKK HLSESRSEFL AVDEYTSLSA SSKNRSLFEK
     GKYPIMLYTE RMHFYKRYNL NGVRNVVFYN LPTDPDFYAQ VVRQIVRNKL KDEELDLNLC
     SIKVMFDRFD TLKLEKIVGL KRASLLVNAE QEVFEFK