ID   UTP25_LACTC             Reviewed;         747 AA.
AC   C5DMP2;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; OrderedLocusNames=KLTH0G10494g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CU928171; CAR25053.1; -; Genomic_DNA.
DR   RefSeq; XP_002555490.1; XM_002555444.1.
DR   AlphaFoldDB; C5DMP2; -.
DR   STRING; 559295.C5DMP2; -.
DR   EnsemblFungi; CAR25053; CAR25053; KLTH0G10494g.
DR   GeneID; 8293768; -.
DR   KEGG; lth:KLTH0G10494g; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; C5DMP2; -.
DR   OMA; ELPGRFR; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000002036; Chromosome G.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..747
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408119"
FT   REGION          1..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..118
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..138
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   747 AA;  85710 MW;  F3D8813D230B757F CRC64;
     MSSLKRSSSA IKGSNEYRSS KSGRKQLRTI RKASGPRRGL AEESANEENN GSETEAEDKL
     AAPELNEPAQ DQRAGGEAYA ALLTLLKAEH GGPARRKTKT DDKKTSADPT SNVKDEEESE
     SRDNEDEEED EDEEAAIENA LMDEHTSGDE DDEGDDGSHQ DDINGVTREG GDATELAAGF
     EEEDKPDTLE IHFNSVSEKD TNALDAAFKA KEVRYRSCKL HVDKNQEFIY SRPTLVNEPA
     SAVSAPDGSQ SLNSYFIKQR LKIQNDLLDS QDKLTPLQKQ IVDPMFQYQD LLYEYEDYDK
     ETEYRDLYAL HVLNHIYKTR DRILKNNQRL QENPDQELLD QGFTRPKVLI VAPTRDAAYD
     ILSKIIQKSG LDQVDKKAKF KDQFFQEALP PSYKPKSFQQ LFKGNTNDFF VLGAKFTRKT
     IKLYSNFYQS DIIICSPLGI QLILENTDKK KRQDDFLSSI ELLVVDQLHS IEFQNMLHLT
     SIFEHINKIP QQQHDADFSR IKMWYINDQA KLFRQTLIFT KFSSPFANSL INGKCRNYAG
     RWKNHRVIFP ENSSLGQLGM RTRLIFQRFD LVGKSVSEEP DSRFKHFCSV IVPNIVKSTG
     YEDGILLYIP DYTDFVRVRN YLREKTTILF GDINEYSEQR QLTSNRAMFQ QGRVKVLLYT
     ERLHHFRRYE IKGVKTVIFY KPPTNPEFFE EVARYLGKSA FLGLADLNIS VVRCLFSKLD
     GLSLERIVGT ERAAVLTHGP NETYEFK