ID   UTP25_LODEL             Reviewed;         752 AA.
AC   A5E1F6;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=LELG_03443;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CH981527; EDK45264.1; -; Genomic_DNA.
DR   RefSeq; XP_001525515.1; XM_001525465.1.
DR   AlphaFoldDB; A5E1F6; -.
DR   STRING; 379508.A5E1F6; -.
DR   EnsemblFungi; EDK45264; EDK45264; LELG_03443.
DR   GeneID; 5232878; -.
DR   KEGG; lel:LELG_03443; -.
DR   VEuPathDB; FungiDB:LELG_03443; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; A5E1F6; -.
DR   OMA; LYTERWH; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..752
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408121"
FT   REGION          1..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..75
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..186
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   752 AA;  87106 MW;  CBE51CFCCD6CF847 CRC64;
     MARQVKRKSG ADRNDGGGKY NSNNDRSVKR GRSELRTVTR TSRRDRGQDE QHNSHGTGGD
     FDIEGNVKDG RENVEQDKEE EEEEEDEDKG KAYEALLTLL KIEQKQEMKS GNKMENGRGL
     ENTGSETGEK DNSAVKDDED EDEDDFGEDE NAGVVLEDQK EEEEEEKEDE DEDEEEEEDD
     EDTPAGINND AFELHFNQPT EEYLEQEDKL VLKENAKWNI HKKESYDDLS LTSITQSPPG
     SSITIPSSLL KQKGTDISEY PLKKRVYTAF ESTYGPSISK LESILLQPIL NYQDINYQYK
     TFLNSSYRKL YALHALNHIY KTRDRILKNT AKLHQLNEDG DDLELRDQGF TRPKVLILLP
     TRDACNEIVE MIIKLSGTDQ QENKKKFTTQ FYTKAETRTN KPGDFQDAFK GNNNDFFCIG
     MKLTRKTLKL YSSFYSSDII LASPLGLSMI LENPDKKKRQ YDFISSIEVL IVDRANQIEM
     QNWDHVNTVM KYINKVPKEF HDADFSRIRM WSINDQAKLL RQTLVFSEYQ TPAINNLVSS
     KSHNLAGKIR FKPVITSENS IMNSIGLRIK QVFQRFPSES PLADPDSRFK FFTNSIIPHL
     LQSSSYGNGI MIYIPSYFDY LRVKQHFKDS TKYNFGAIDE YSSQSKLTRT RHEFALGKIQ
     IILYTERLHY FRRYEISGVK NLIMYVPPSN PLFYKELIRF IGKSVFKEEC DLDLTWAKLI
     YSKWDANALE RIVGNERAPV LCSSQNEQYE FR