ID   UTP25_NEOFI             Reviewed;         728 AA.
AC   A1D3E2;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=utp25; ORFNames=NFIA_016310;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; DS027688; EAW22935.1; -; Genomic_DNA.
DR   RefSeq; XP_001264832.1; XM_001264831.1.
DR   AlphaFoldDB; A1D3E2; -.
DR   STRING; 36630.CADNFIAP00001000; -.
DR   PRIDE; A1D3E2; -.
DR   EnsemblFungi; EAW22935; EAW22935; NFIA_016310.
DR   GeneID; 4591884; -.
DR   KEGG; nfi:NFIA_016310; -.
DR   VEuPathDB; FungiDB:NFIA_016310; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..728
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408124"
FT   REGION          1..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..147
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   728 AA;  82426 MW;  FBCE7CC0815A8A5A CRC64;
     MPPVRNRGGR FSRGRGKGPR GQTNRRNGFT TSRVEDVEPE DHSDNESHLS HEPAGDEMDH
     ETQMDDVSSD SDDDEAQQTA RPYNELIQLL QVNAEPKGPA RKRRKVEHNG GEKRDAVPAA
     NGEEDDAVLL GDDDLQEQEP SDEEEEDHPK EADGKYESDD EEDANDPFET HFSAVDESEL
     ALKIKSAEEK KWKNTKKEIG SGLKLVRAIP DIGEGDVSLL PAMKHFSIVK LKKKLYGPAT
     ERIPAISGDA QHIAPYIFGY QDVLYGARTT SNSSAMRDIL AVHAVNHILK TRDRVLKNNS
     RIAKEQDADL DLRDQGFTRP KVLYLLPTRQ ACVRAVESIT RFFQPEQQEN KKRFLDSFSA
     ADDKSWENKP EDFRELFGGN DDDMFRLGLK FTRKTMKYFS QFYNSDIILA SPLGLRTIMD
     QADAKKRDHD FLSSVELVIV DHADALLMQN WDHVGYILDH LNLQPKEAHG CDFSRVRTWY
     LDNHARFVRQ MIVSASFITP EINSLFSTHM QNFAGKIKVT PVYAGAISEV PLPVSVKQTF
     SRFDSLTPTK DPDARFKHFT TTVLSSLVRN ITSSRDKSSA GGTLIFIPSY LDFVRVRNYF
     ATSSQTTNVS FGAISEYSEV REMTRARTHF MNGRHSVLLY TERLHHFRRY QIRGVKRIVM
     YGVPENPLFW GEIVGFLGLD PAGVVDAAEG GVRALFSRWD ALKLERIVGT KRVGNMLREK
     GGDTFTFV