ID   UTP25_NEUCR             Reviewed;         751 AA.
AC   Q9P749;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=utp25; ORFNames=1A9.190, NCU01022;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL353817; CAB88516.2; -; Genomic_DNA.
DR   EMBL; CM002240; EAA32398.1; -; Genomic_DNA.
DR   PIR; T48719; T48719.
DR   RefSeq; XP_961634.1; XM_956541.2.
DR   AlphaFoldDB; Q9P749; -.
DR   STRING; 5141.EFNCRP00000004408; -.
DR   EnsemblFungi; EAA32398; EAA32398; NCU01022.
DR   GeneID; 3877809; -.
DR   KEGG; ncr:NCU01022; -.
DR   VEuPathDB; FungiDB:NCU01022; -.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; Q9P749; -.
DR   OMA; KYFRQTI; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR   GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..751
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408125"
FT   REGION          1..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..113
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..156
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..195
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   751 AA;  85059 MW;  F16FFC1B5FFC991D CRC64;
     MAIRGRGGDR GGGGRGGGGR GRGGAGGFRG RGGSRGGGSR GGARGASRGR GRGSSRGGAR
     GGFGPRSSKF NDARLADKDE EEDEEEDISE EESNVSEDEI EESEEEDEEE DAQSGQPYMS
     LLKSFQSATK TKKRKLDHPE EEGPNKVTKT KDDDNSDDED NEKVTEDVDA VDEPEEDPQD
     APLEDLFDED DDLDDSDPFE THFTAPDEAT FQARIKAIQA NKWRTDRIAK NSNRIYYNTP
     ETGDSAEQKL PHSISGVGDL KLKQRLAESM AKHTEFDEAE KAVAPLLFNY QDMLYCNRSV
     ASSESIRRMA CLHALNHVFK TRDRVIKNNT KLQRDDTLEL RDQGFTRPKV LMILPTRQSC
     VKMVEMICKV AAPEQQENRK RFDDGYVDKS TKFSDDKPED FRDLFAGNDD DMFRLGMKFT
     RKTIKYFSQF YNSDIIFASP LGLRMAIGSE EEKKKLDYDF LSSIELVIVD QADALLMQNW
     EHVEFIFEHL NLQPRDAHGC DFSRVRSWYL DDQAKYFRQT VIFSAFNTPE LAELQRLYCH
     NWAGKARLQA EYPGVIQYLG VKTRQTFSRF DAASIAADPD ARFAYFTKAI VPTLVKRAAK
     DAAGTLIFIP SYLDFVRVRN YFANNPAVES VTFGNISEYA DTPEASRARS HFLTGRHRVL
     LYTERAHHFR RYAIKGVKRV IFYGLPDNPI FYREIAGGYL QKSEQALMLE HGQGHVKVMF
     SKYDIMKLER IVGTKRAGKM ITEQGDTFDF V