ID   UTP25_PARBA             Reviewed;         732 AA.
AC   C1GPD0;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   04-FEB-2015, sequence version 2.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=PAAG_00375;
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01;
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KN293992; EEH36052.2; -; Genomic_DNA.
DR   RefSeq; XP_015700331.1; XM_015843996.1.
DR   AlphaFoldDB; C1GPD0; -.
DR   STRING; 502779.C1GPD0; -.
DR   EnsemblFungi; EEH36052; EEH36052; PAAG_00375.
DR   GeneID; 9100923; -.
DR   KEGG; pbl:PAAG_00375; -.
DR   VEuPathDB; FungiDB:PAAG_00375; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..732
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408126"
FT   REGION          1..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..61
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..77
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..154
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..171
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   732 AA;  82307 MW;  3B0B3E7DBBF0119E CRC64;
     MAAGRGRGGS RPFSVRGGRG RGQKGGRGSR RPTFEASRVA EAHHEDSSED GSVHLGSDLD
     AEDQLEAPDE SSSSSSDDEE DENRTEKPYN TLLQLLNTGQ GVGGPARKRR KMDHNSKKVD
     VEVKGSDESD AEGLLLESEG EESSEGEEME DMPMDEVRTE NSGDENDASD PFEIHFSNVD
     STLLSQKIKA ISSKGWQSHK SELPGKLRLM ASQPNTEGHI IQVLPATQGV DNLKLKQKLA
     KHAGDHISKL DSLASSLVPY IFGYQDLLFG ARTLSNSATF RDLYCLHVLN HILKTRDRVL
     KNNSRLQKEP ESDLELRDQG FTRPKVLIIL PTRQACVRVM ESITKLYQAE QQENKARFYE
     TFSAADDKSW EHKPDDFREL FGGNDDDMFR LGLKFTRKTI KYFSQFYNSD IILASPLGLR
     MVMDKEDGEK QDFDFLSSIE IAIVDQADAL LMQNWEHTEY VFSHLNLQPK ESHGCDFSRV
     RNWYLDDQAK YVRQTLTFSS FITPEINALF SSRMQNTAGK IKATPTYEGA ILDIPLPVPV
     KQTFSRFNSS SPVKDPENRF KYFTSTVLSS LIRSFTGRGG TPRASGTLIF IPSYLDFVRI
     RNYLATSSQT EHLSFGAISE YTSVRDVARA RTHFFSGRHS VLLYTERTHH FRRYQIRGVK
     RIIMYGVPEN PVFWGEVVGF LGLDPAGAAE AAEGGVRALF SKWDALKMER IVGTKRLGNM
     LMEKGGDTFS FV