ID   UTP25_PARBD             Reviewed;         735 AA.
AC   C1G2D1;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=PADG_02297;
OS   Paracoccidioides brasiliensis (strain Pb18).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pb18;
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; KN275958; EEH46147.1; -; Genomic_DNA.
DR   RefSeq; XP_010757759.1; XM_010759457.1.
DR   AlphaFoldDB; C1G2D1; -.
DR   SMR; C1G2D1; -.
DR   STRING; 121759.XP_010757759.1; -.
DR   EnsemblFungi; EEH46147; EEH46147; PADG_02297.
DR   GeneID; 22581803; -.
DR   KEGG; pbn:PADG_02297; -.
DR   VEuPathDB; FungiDB:PADG_02297; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   OMA; KYFRQTI; -.
DR   Proteomes; UP000001628; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..735
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408127"
FT   REGION          1..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..77
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..157
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..174
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   735 AA;  82475 MW;  7EF5C18F0C7A2A4F CRC64;
     MAAGRGRGGS TPFNVRGGRG RGQKGGRGSR RPTFEASRVA EAHHGGSSED GSVHSGSDLD
     AEDQLEAPDE SSPSSSDDEE DENKTEKPYN TLLQLFNAGQ DAGGPARKRR KMDHNSKKVD
     VEVKGSDESD AEGLLLESEG EESSEGEEME DMEDMPMDEV RTENSGDEND ASDPFEIHFS
     NVDSTLLSQK IEAISSKGWQ SHKSELPGKL RLMASQPNTE GHTIQVLPAT QGVDNLKLKQ
     KLANHAGDHI SKFDSLASSL VPYMFGYQDL LFGARTLSNS AMFRDLYCLH ALNHILKTRD
     RVLKNNSRLQ KEPESDLELR DQGFTRPKVL IILPTRQACV RVMESITKLY QPEQQENKAR
     FHETFSAADD KLWEHKPDDF RELFGGNDDD MFRLGLKFTR KTIKYFSQFY NSDIILASPL
     GLRMVMDKED GKKQDFDFLS SIEIAIVDQA DALLMQNWEH TEYVFAHLNL QPKESHGCDF
     SRVRNWYLDD QAKYVRQTLT FSSFITPEIN ALFSSRMQNT AGKIKATPTY EGAILDIPLP
     VPVKQTFSRF NSSSPVKDPE NRFKYFTSTV LSSLIRSSTG RGGTPRASGT LIFIPSYLDF
     VRIRNYLATS SQTEHLSFGA ISEYTSVRDV ARARTHFFSG RHSVLLYTER THHFRRYHIR
     GVKRIIMYGV PENPVFWGEV VGFLGLDPAG TAEAAEGGVR AMFSKWDALK MERIVGTKRL
     GNMLTEKGGA TFSFV