ID   UTP25_PICGU             Reviewed;         716 AA.
AC   A5DFC2;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=PGUG_01973;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CH408156; EDK37875.2; -; Genomic_DNA.
DR   RefSeq; XP_001486302.1; XM_001486252.1.
DR   AlphaFoldDB; A5DFC2; -.
DR   STRING; 4929.XP_001486302.1; -.
DR   PRIDE; A5DFC2; -.
DR   EnsemblFungi; EDK37875; EDK37875; PGUG_01973.
DR   GeneID; 5128130; -.
DR   KEGG; pgu:PGUG_01973; -.
DR   VEuPathDB; FungiDB:PGUG_01973; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; A5DFC2; -.
DR   OMA; ELPGRFR; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..716
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408132"
FT   REGION          1..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..88
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..141
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..158
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   716 AA;  82626 MW;  BE22A3BA34E7C1B2 CRC64;
     MQESGACRKK PAMPSRNAGS HLVVMKRIQR NGDGAMKRQK HGRRELREVK RTSRRSAKSE
     DFSGAEDENN GENETEVAVN NSESGEQEGV DDTGMAYNAL LTLLGSEKPE KPTKRRKNDE
     AGVEEINEDD LEIHLTKSDD ESDEENEPEV ASDDEESDEK FNAFDFHFNQ PSEDYMEKAS
     QSVTSKWNNT TKETIDEYVV STSTPSCMNK ESVKLGISSI KKRVRDVYSE KHPSKISGID
     ASLLDSMLNY KSVLYPYKHY NNTFYRELYS MHAINHVFKT RDNILKNTEK IKHAQEMALE
     GKSHEDKEYR DQGFTRPKVL ILLPTRNAAY EVVENILKYS GSEQQENKKK FKAQFNSNDV
     PPETKPQDFR DAFKGNNNDF FCLGMKFTRK SAKLYSSFYS SDIIIASPLG LSMILENPDK
     KKRQYDFLSS IEVFIVDRAT QIEAQNWAHV NLVLKYLNKV PKEFHDADFS RIRMWYINDQ
     APLVRQTLVF CEYTTPPITS LVSSKSVNIG GRVRYKPIYT SKNCIMNSIG LRLKQIFQRF
     SSSSPMEDSE NRFKFFINSM LPSLLSSTSY SDGILVYIPS YFDYVRIKNY MRNSTKFTFE
     GIDEYSTQSK LTRYRQQFIS GKVKILLYTE RLHYFRRFEI NGVKTLLMYG VPSNPLFYKE
     LVRCIGKSVF KEVADIDLSF VKVMYSQWDA IALERIVGGD RAPVLCSGTN EMYEFR