ID   UTP25_PICST             Reviewed;         722 AA.
AC   A3LXV1;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=PICST_84833;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000500; ABN67527.2; -; Genomic_DNA.
DR   RefSeq; XP_001385556.2; XM_001385519.1.
DR   AlphaFoldDB; A3LXV1; -.
DR   STRING; 4924.XP_001385556.2; -.
DR   EnsemblFungi; ABN67527; ABN67527; PICST_84833.
DR   GeneID; 4839837; -.
DR   KEGG; pic:PICST_84833; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; A3LXV1; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000002258; Chromosome 6.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..722
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408134"
FT   REGION          1..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..79
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..145
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   722 AA;  84056 MW;  E2D71C192C255EBE CRC64;
     MARQVKRRPH ASARPESSSD SKKPKLKHGR HQMRTVTRTA RRPGQQDFEE ESQDTYDNQQ
     LGEDGQNDEE SEDEQEIEQE SGKAYEALLT LLKSDHKESK PARKSDKVEE NQDEEEEDDE
     EIAGANVQNE EDQDNEDDNE DDEDSARGLA QDPLEAHFNR VEDSYIDNQE RLVIKEREKW
     TTVEKKTYDN LGYSSLTQSP PGRAISIPSK TKVKISDFFI KKRVLDAFEA TYPSDFEKLS
     PLDLALLEPM MKYQDINFPY KTFSNTSYRK LYALHALNHI YKTRDRIIKN TTKLNNYREA
     LKNGTANLDS QEPEFRDQGF TRPKVLILLP TRNSCYELVE LLIKLSGCEQ QENKKKFMNQ
     FYAKELPPDT KPLDFRDSFK GNNNDFFCLG LKLTRKSLKL YSSFYSSDII IASPIGLSMI
     LENPDKKKRQ YDFVSSIEVL IVDRANQIEM QNWENVATVM RYVNKIPKDF HDADFSRIRM
     WSINDQSKLL RQNLIFSEYL TPNINNLITS KSFNIGNKTK FKPIINSNNC IMNSIGLKLK
     QIFQRFDSPS PVSDPEVRFK FFINTVLPSL MKSSSYSDGI MIFVPSYFDY LRIKHHLKSS
     TKFNFGSIDE YSSQSKSTKA RQQFMAGKIN IMLYTERLHY FRRFEISGVK TMLMYGLPSN
     PVFYKELVRF IGKSVFREQC DLDLAFVKIL FSKWDAVTLE RVVGNERAHA LCNSPNELFE
     FR