ID   UTP25_PODAN             Reviewed;         660 AA.
AC   B2B4I8; A0A090CC39;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; OrderedLocusNames=Pa_2_1430; ORFNames=PODANS_2_1430;
OS   Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
OS   (Pleurage anserina).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Podosporaceae; Podospora;
OC   Podospora anserina.
OX   NCBI_TaxID=515849;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX   PubMed=18460219; DOI=10.1186/gb-2008-9-5-r77;
RA   Espagne E., Lespinet O., Malagnac F., Da Silva C., Jaillon O., Porcel B.M.,
RA   Couloux A., Aury J.-M., Segurens B., Poulain J., Anthouard V.,
RA   Grossetete S., Khalili H., Coppin E., Dequard-Chablat M., Picard M.,
RA   Contamine V., Arnaise S., Bourdais A., Berteaux-Lecellier V., Gautheret D.,
RA   de Vries R.P., Battaglia E., Coutinho P.M., Danchin E.G.J., Henrissat B.,
RA   El Khoury R., Sainsard-Chanet A., Boivin A., Pinan-Lucarre B., Sellem C.H.,
RA   Debuchy R., Wincker P., Weissenbach J., Silar P.;
RT   "The genome sequence of the model ascomycete fungus Podospora anserina.";
RL   Genome Biol. 9:R77.1-R77.22(2008).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX   PubMed=24558260; DOI=10.1534/genetics.113.159988;
RA   Grognet P., Bidard F., Kuchly C., Tong L.C.H., Coppin E., Benkhali J.A.,
RA   Couloux A., Wincker P., Debuchy R., Silar P.;
RT   "Maintaining two mating types: Structure of the mating type locus and its
RT   role in heterokaryosis in Podospora anserina.";
RL   Genetics 197:421-432(2014).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU640366; CAP72713.1; -; Genomic_DNA.
DR   EMBL; FO904937; CDP25110.1; -; Genomic_DNA.
DR   RefSeq; XP_001910888.1; XM_001910853.1.
DR   AlphaFoldDB; B2B4I8; -.
DR   STRING; 5145.XP_001910888.1; -.
DR   EnsemblFungi; CAP72713; CAP72713; PODANS_2_1430.
DR   GeneID; 6195830; -.
DR   KEGG; pan:PODANSg7930; -.
DR   VEuPathDB; FungiDB:PODANS_2_1430; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000001197; Chromosome 2.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..660
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408135"
FT   REGION          1..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..103
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  76366 MW;  8950B1A524A5E16A CRC64;
     MSLVDSDSDE EEDATSAQPY VNLMKRLIET NPQKAKRRKL DHAPAEDNQP EAAPAPESGD
     EDERDDEQEE QRDVDEVEEA EEDTADIQPE DLFDEDDDLD ETDPFETHIS NPDENTVPPR
     VRAAQNGKWK MQRQPFESTR AYWSYPQTED GQELPLPAPI TSVSNLHLKK RLKEVMEFKR
     STFGVVEKTV APFLFNYRDM LYCDRTVGSS QDLRNLAALH ALNHLYKTRD RVIKNNARLA
     KADANEDLEL RDQGFTRPKV LMLLPTRQSC VKMVDSILSV CQPDQQENRK RFEDGYIEKL
     SKFSDDKPED FRDLFSGNDD DMFRLGMKFT RKSVKYFSQF YNSDIIFASP LGLRMAIGSE
     EERKVDFDFL SSIELVIVDQ ADALLMQNWE HVEFIFEHLN IQPKDAHGCD FSRVRSWYLD
     DQAKYFRQTV VFSAFNTPEL AELMRAHCHN WAGKVRLQQE CPGTIQYLPV KARQTFSRFD
     APTVAADPDA RFNYFTKAIV PLLTKRNAKD ANSTLIFIPS YLDFVRVRNF FANNPIVEAV
     TFGTISEYAD IPEASRARSH FLTGRHKVLL YTERAHHFRR YQIKGVKRVI MYSLPDNPLF
     YREIAGGYLQ KSEQSLMVEH GQGVVRVMFS KYDLMKLERI VGTSRVGKMI KEQGDTFDFV