ID   UTP25_SCHJY             Reviewed;         640 AA.
AC   B6JX19;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=utp25; ORFNames=SJAG_00945;
OS   Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=402676;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=yFS275 / FY16936;
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; KE651166; EEB05920.1; -; Genomic_DNA.
DR   RefSeq; XP_002172213.1; XM_002172177.2.
DR   AlphaFoldDB; B6JX19; -.
DR   STRING; 4897.EEB05920; -.
DR   EnsemblFungi; EEB05920; EEB05920; SJAG_00945.
DR   GeneID; 7050817; -.
DR   VEuPathDB; FungiDB:SJAG_00945; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000001744; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0019843; F:rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..640
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408138"
FT   REGION          24..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..70
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   640 AA;  74268 MW;  A07045F45DBEA17B CRC64;
     MSDLSKDELA NDAYQALLVM LKSDGKHKLK EEEAPRKRQK RNKVTEKLSV AQEPEEDEEN
     IEDAEQESAS EVQELLEAGD HLQEDEVPKE NDPFHTHYEA PSTEELASAI TKLNNGEIKK
     ENLDCSLGVK QIQQVPSEKL SLRLSSFAPA NVSDLKLKQR LLRSYLSIKP SGNMTNLQCE
     LAKHIFNYED VLFSNVSSKC DTLVRNLYTL HAINHVYKVR DHVLKNSAKL SQNQELEFRD
     QGYTRPKVLI LLPTRNACLQ FVETLIQFTG AEQVENRKRF SNEFSIETEV ISEKKPEDFR
     QLFAGNTDDM FRLGIKFTRK TIKLFSQFYN SDIIVASPLG LRMAIGNKSD KKRDFDYLSS
     IEVAIVDQAD ALLMQNWEHL EYVFEHMNKL PKNSHGCDFS RVRPWYLEEQ SRYLRQTLMF
     SHYNAVDINA FYLHEMLNLA GRVKFHPKQK GVLNSLGYHI TQTFARVQTE SLLKVPDARF
     EHFTSTLVPQ LLKNAMGGIL VYIPSYFDYV RVRNYFEDEA ISYVSICEYT KNSDISRART
     QFYQNRKQIM LYTERAHHFR RFDFRGVRGI IMYAPPTNAQ FYVELTRMPM RSISDGILDA
     DAAKCRVLYT KYDMIPMEPI VGSERVTNMC KGKHDIYEFV