UTP25_SCHPO
ID UTP25_SCHPO Reviewed; 652 AA.
AC O74974;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE Short=U3 snoRNA-associated protein 25;
DE AltName: Full=U three protein 25;
GN Name=utp25; ORFNames=SPCC1827.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA19309.1; -; Genomic_DNA.
DR PIR; T41162; T41162.
DR RefSeq; NP_588547.1; NM_001023534.2.
DR AlphaFoldDB; O74974; -.
DR SMR; O74974; -.
DR BioGRID; 275478; 2.
DR STRING; 4896.SPCC1827.01c.1; -.
DR iPTMnet; O74974; -.
DR MaxQB; O74974; -.
DR PaxDb; O74974; -.
DR EnsemblFungi; SPCC1827.01c.1; SPCC1827.01c.1:pep; SPCC1827.01c.
DR GeneID; 2538900; -.
DR KEGG; spo:SPCC1827.01c; -.
DR PomBase; SPCC1827.01c; utp25.
DR VEuPathDB; FungiDB:SPCC1827.01c; -.
DR eggNOG; KOG2340; Eukaryota.
DR HOGENOM; CLU_018705_0_1_1; -.
DR InParanoid; O74974; -.
DR OMA; LYTERWH; -.
DR PhylomeDB; O74974; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O74974; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005730; C:nucleolus; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010678; UTP25.
DR PANTHER; PTHR12933; PTHR12933; 1.
DR Pfam; PF06862; UTP25; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..652
FT /note="U3 small nucleolar RNA-associated protein 25"
FT /id="PRO_0000372381"
FT REGION 29..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 75652 MW; 96BB732F2273DE6B CRC64;
MAIESDLDGA SMDELAGKSY EALLYLMNKN KKRKPEKKDD KEKSSKKVQK KNKVIESLNE
MEVEMEDENE NENDEQEAIQ YYINVESQDA DETLHQEAQD SSEDPFHQHF DYDDSEVIKN
SIAAYDEGKL CKSIEESKLG VSQSFFPDVT KRLPCSCLSE IKNIDDLGLK QRILDSYKKQ
KPSGQLTSMQ IELAKAMFNY QDVFFTNMSM KSHKLGTSLL ALHALNHVFK TRDRVLKNSA
RISQNPELEF RDQGYTRPKV LILLPTRNSA FEFINLLISY SGTNQVENRK RFDNEFSIEK
EVISEKKPED FRYLFSGNTD DMFRLGVKFT RKTVKLFSQF YNSDIIVASP LGLRLAIGNK
GDKKRDLDYL SSIEIAMVDQ AHALVMQNWE HIECIFDELN GLPKEAHGCD FSRVRPWYLD
QQARYMRQTI LFSQYNNLDI NSFFSHYMSN IAGKVKFRSL LHGVLNRLGY KVTQTFVRIS
VDSIIKVPDA RFSYFTGSIL VQLKKYSQSG ILVYIPSYFD FVRVRNYMDE EGINYSAISE
YSSVSDMTRA RNLFYQGRTN IMLYTERAHH FRRFDFRGVK AVVMYGPPTN PQFYVELVRM
PMRTISEGNL DSDAAKCRIM YTKFDSICLE GIVGYQRVSN MCHGKHEVFE FL
