ID   UTP25_SORMK             Reviewed;         742 AA.
AC   D1Z6B1; F7VX89;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=SMAC_02709;
OS   Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX   NCBI_TaxID=771870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell;
RX   PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA   Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K.,
RA   Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S.,
RA   Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.;
RT   "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT   Sordaria macrospora, a model organism for fungal morphogenesis.";
RL   PLoS Genet. 6:E1000891-E1000891(2010).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CABT02000011; CCC10131.1; -; Genomic_DNA.
DR   RefSeq; XP_003352275.1; XM_003352227.1.
DR   AlphaFoldDB; D1Z6B1; -.
DR   STRING; 771870.D1Z6B1; -.
DR   EnsemblFungi; CCC10131; CCC10131; SMAC_02709.
DR   GeneID; 10809903; -.
DR   KEGG; smp:SMAC_02709; -.
DR   VEuPathDB; FungiDB:SMAC_02709; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; D1Z6B1; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000001881; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..742
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408140"
FT   REGION          1..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..57
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..121
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..160
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..207
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   742 AA;  83900 MW;  3A21848052CBF7EB CRC64;
     MAFRGRGGDR GGGGRGRGGG GGFRGRGGSR GGGSRGGDRG GSRGRGRGGD RGASRGRGRG
     SSRGGARGGF GPRPSKFNDA RLADKDEDGS EEDDISEDES NVSEEEIEGS EEEDEEGEEE
     AQSGQPYMSL LKSFQSATKS KKRKLDHTEE EGPNKATKTE DDDDSDDEDD DEEVKEDVDA
     VDEPEEDPQD APLEDLFDED DDLDDSDPFE THFAAPDEAT FQARIKAVQA NKWRTDRIAQ
     NSNRIYYNTP ETGDSTERKL PHSISGVADL KLKKKLAESM AKHTEFDEAE KAVAPLLFNY
     QDMLYCNRTV ASSESIRRMA CLHALNHVFK TRDRVIKNNT KLQRDDTLEL RDQGFTRPKV
     LMLLPTRQSC VKMVEMICEV ASPEQQEHRK RFDEGYVDKS TKFSDDKPED FRDLFSGSDD
     DMFRLGMKFT RKTIKYFSQF YNSDIIFASP LGLRMAIGSE EEKKKLDYDF LSSIELVIVD
     QADALLMQNW EHVEFIFEHL NLQPRDAHGC DFSRVRPWYL DDQAKYFRQT VIFSAFNTPE
     LAELQRLHCH NWAGKARLHP EYPGVIQYLG VKTRQTFSRF DAGSIAADPD ARFAYFTKAI
     VPTLVKRAKD AAGTLIFIPS YLDFVRVRNY FANNPDVASV TFGNISEYAD TPEASRARSH
     FLTGRHRVLL YTERAHHFRR YAIKGVKRVI FTKSEQSLML EHGLGTVKVM FSKYDIMKLE
     RIVGTKRAGK MITEQGDTFD FV