ID   UTP25_TALMQ             Reviewed;         734 AA.
AC   B6Q702;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=utp25; ORFNames=PMAA_025460;
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; DS995899; EEA27692.1; -; Genomic_DNA.
DR   RefSeq; XP_002144207.1; XM_002144171.1.
DR   AlphaFoldDB; B6Q702; -.
DR   STRING; 441960.B6Q702; -.
DR   EnsemblFungi; EEA27692; EEA27692; PMAA_025460.
DR   GeneID; 7022000; -.
DR   KEGG; tmf:PMAA_025460; -.
DR   VEuPathDB; FungiDB:PMAA_025460; -.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   OrthoDB; 257318at2759; -.
DR   PhylomeDB; B6Q702; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..734
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408130"
FT   REGION          1..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..27
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..65
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..139
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..170
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   734 AA;  83932 MW;  118812FE0D6CCAFF CRC64;
     MPPPRKRGRG SFRGSSRGAH RGRGHARGGR NSFQTSRVDE KREIESSDDE EQFNGFEDEV
     SGGEEPMQDV EIASEPSSED EEPATERSYN SLLQLLNAKS EPSHARKRRK LDHLESKQDK
     PNREVEIQET TKEPEEQDVL ENQEASEEED NVEVDRAGES DDEDEEDASD PFETHISSPD
     ETEISKRVKE ITAGKWRSIK SSLLETFRLI YNIPDEEGGS WSIPSAVKNT RSLKLKKRLI
     PTAAERIPSF SGISQNIASL VFNYSDVLFG DRKASNAAQL RDLLSLHALN HVLKTRDRVI
     KNNARLSRDI NPDIELRDQG FTRPKVLIIL PTRQACVRFI DSISRLYQPE QQENRKRFMD
     EYNAKDNESW ESKPDDFRDL FGGNDDDMFR IGLKFTRKTI KYYSQFYNSD IILASPLGLR
     TIMDKEDEKK RDHDFLSSIE IAIVDHADGL LMQNWEHVEY IFEHLNLQPK EAHGCDFSRV
     RTWYLDDRAR YIRQTIVTTS FLTPEMNSLF SQHMQNVAGK AKILPQYNGA ITEVALPITV
     KQTFSRFDST FALKEPDLRF KYFTTAILPA LARSVTGKGE GNGAGTLIFI PSYLDFVRVR
     NFFSTSSRAT NISFGAISEY TEQSEMSRSR SHFMSGRLSV LLYTERAHHF RRYNIRGVKH
     VIFYGLPENP IFFREVVQYL GLDPGALAGS AGAETLDVRA VFSKYDAFKL ERIVGTQRAA
     NMLKEKGGDT FRFV