ID   UTP25_TALSN             Reviewed;         729 AA.
AC   B8LVD6;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=utp25; ORFNames=TSTA_073440;
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS   1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441959;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; EQ962652; EED23955.1; -; Genomic_DNA.
DR   RefSeq; XP_002341342.1; XM_002341301.1.
DR   AlphaFoldDB; B8LVD6; -.
DR   STRING; 441959.B8LVD6; -.
DR   EnsemblFungi; EED23955; EED23955; TSTA_073440.
DR   GeneID; 8103959; -.
DR   VEuPathDB; FungiDB:TSTA_073440; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; B8LVD6; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   PhylomeDB; B8LVD6; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..729
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408141"
FT   REGION          1..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..77
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..165
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   729 AA;  83055 MW;  4947C3D33268AD9F CRC64;
     MAPPRKRGRG SFRGSSRGAR KPGNARGGRN SFQTSRIDEK REIESSDEEN QFNGFEDDVS
     GDDEPVQDEE IVDSSSEDEE ATTERPYNSL LQLLNANSET KHARKRRKLD RAGSKSQDIR
     DVEIQASKEV EEQDVLENQE ASEEEDNAEA DKAGESEDED EDASDPFETH IASLDEAETT
     KRVNEIKSDK WRSIKSSLPE NFRLIYNIPD GEGGSWSMPS AVKTTRSLKL KKKLVSRAAE
     ILPSFEGVAQ NIASLVFNYS DVLFAGRTPS NAAQMRDLLS LHSLNHVLKT RDRVIKNNAR
     LSRDTNEDIE VRDQGFTRPK VLVILPTRQA CVRFVESISK IYQPEQQENR KRFMDEYHAE
     DNESWASKPD DFRDLFGGND DDMFRIGLKF TRKTIKYYSQ FYNSDIILAS PLGLRTIMDK
     EDEKKRDHDF LSSIEIAIVD HSDGLLMQNW EHVEYICEHL NLQPKEAHGC DFSRVRTWYL
     DDRARYIRQT IVLTSFLTPE INSLFSQHMQ NIAGKSKILP QYNGAITEVA LPITVKQTFS
     RFDSTFALKD PDLRFKYFTT AILPALARSV TGKGEGNGAG TLIFIPSYLD FVRVRNFFAT
     SSQATNISFG AISEYTEQSE MSRARSHFMN GRLSVLLYTE RAHHFRRYNI RGVKHIIFYG
     LPENPIFFRE IVQYLGQDPG VLAGTAGAEN LDVRAVFSKY DAFKLERIVG TQRAGNMLKE
     KGGDTFRFV