ID   UTP25_TRIVH             Reviewed;         714 AA.
AC   D4DB32;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=TRV_04331;
OS   Trichophyton verrucosum (strain HKI 0517).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HKI 0517;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; ACYE01000220; EFE40866.1; -; Genomic_DNA.
DR   RefSeq; XP_003021484.1; XM_003021438.1.
DR   AlphaFoldDB; D4DB32; -.
DR   EnsemblFungi; EFE40866; EFE40866; TRV_04331.
DR   GeneID; 9578465; -.
DR   KEGG; tve:TRV_04331; -.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   Proteomes; UP000008383; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Ribonucleoprotein; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..714
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408142"
FT   REGION          1..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..54
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..145
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   714 AA;  80537 MW;  F61A8E87B7298BD8 CRC64;
     MAIQHKKGGG HRGRGSKTGR SRGRKFETSR LKDVREDESS GGEEDVDGQP TEDMNDSEGT
     DVSSESGLDE PPKENSYSTL LKLLNTDAKS NEPARKKRKI KANEPDANPV EVSIPTADDT
     EQMDEVADTE ASASEDENMD DEDIPDEDYA EDIGTDGRND MFELHFGNPD ETELSHKIQA
     CSKAWKSTKA DLIDGLYSVV SMPDAGGISS ASLPTTPSPA DLKLKQKLAR NAVSFDRLNS
     CLTPYIFGYH DTLFCSRTTQ NSAKLRDLYC LHALNHVLKT RDRVIKNSAI LSRENNGDVE
     LRDQGFTRPK VLIILPTRQA CVRVINSFTK IYPMEQQENK KRFMDSFSAA DSDEWAHKPD
     DFKELFGGND DDMFRLGFKF TRKSLKFFSK FYSSDIILAS PLGLRTAIEK EGGKKNENDF
     LSSIEMVIVD HADALMMQNW DHVEYIFSNL NLQPKEAHGC DFSRVRQWYL DGHGKFLRQT
     LVFSAFNTPE LNALYNTQMQ NVFGKAKIMS KYEGAMLNLR LPISVKQTFS RFDSASPLKD
     PEARFQYFTR TVLASLARGW TESSPRKKSG GTLIFIPSYL DFVRVRNHFA NSSQTENISF
     GLISEYTSVR DSSRARSHFM NGRHSVLLYT ERAHHFRRYN IRGVTNIVMY GLPDNPIFWG
     DLIEYLGSAA GGTSTPTVRV LFSKWDALKL ERIVGTARVR SMLLEKGGDT FTFV