ID   UTP25_UNCRE             Reviewed;         715 AA.
AC   C4JTH6;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=UREG_05765;
OS   Uncinocarpus reesii (strain UAMH 1704).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX   NCBI_TaxID=336963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 1704;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CH476617; EEP80923.1; -; Genomic_DNA.
DR   RefSeq; XP_002585076.1; XM_002585030.1.
DR   AlphaFoldDB; C4JTH6; -.
DR   STRING; 336963.C4JTH6; -.
DR   EnsemblFungi; EEP80923; EEP80923; UREG_05765.
DR   GeneID; 8443022; -.
DR   KEGG; ure:UREG_05765; -.
DR   VEuPathDB; FungiDB:UREG_05765; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; C4JTH6; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000002058; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..715
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408143"
FT   REGION          1..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..134
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..153
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  80999 MW;  005C73891A494E45 CRC64;
     MAVKGAAKGR GPPRRKQPRF ETSRVQDLDD REPLNGEQVV SEDALNEASD AEYSVSSSDN
     EEEEKSTDKP YNVLLQLLNA SEDSIGPAKK KRKLKHKEKN VKQQTEATKE ASPGKGDLDL
     QDDLDVKEAE NTESDNEQVE NDEAEGSEDE ADSGSDPFEI HFSQPDEAQL SKRIEATSQK
     WRTSRQTLPA GMRFTAVYPD VGEEQNLHRA SLHSPKDLTL KRKLSEAASV HLPQFDAPNT
     SVAPYLFGYY DMIYGGRTTG NAAKLRDMYC LHALNHIIKT RDRVIKNNAR VPKEGEDIEI
     RDQGFTRPKV LIILPTRQAC VRVVDSISKF YQAEQQENRK RFMETFSTAD DDTWEDKTED
     FRELFGGNDD DMFRLGLKFT RKTVKFFSQF YSSDIILASP LGLRTAIEKE DGKKIEYDFL
     SSIELVIVDH ADALLMQNWD HVEYIFSHLN LQPKEAHGCD FGRVRTWYLD GNAKYLRQTL
     ILTSFITPEI NSLFSHHAYN VFGKIKIDST YPGAILDVPV PVPVRQTFSR FDSLSPVKDP
     DARFKYFTST VLSSLAKNWS SSGKSSAAGT LIFIPSYLDF VRIRNYFATS SQTTNLSFGA
     ISEYSSPRDV ARARSHFMNG RHTVMLYTER LHHFRRYKIR GVKRVVMYGV PENPVFYKEI
     AGFLGIDPAA VGEAAEKGVR ALFSKWDALK LERIAGTKRM GSMMLEKGGD TFTFT