ID   UTP25_VANPO             Reviewed;         704 AA.
AC   A7THH1;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=Kpol_1039p46;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; DS480391; EDO18295.1; -; Genomic_DNA.
DR   RefSeq; XP_001646153.1; XM_001646103.1.
DR   AlphaFoldDB; A7THH1; -.
DR   STRING; 436907.A7THH1; -.
DR   PRIDE; A7THH1; -.
DR   EnsemblFungi; EDO18295; EDO18295; Kpol_1039p46.
DR   GeneID; 5546576; -.
DR   KEGG; vpo:Kpol_1039p46; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; A7THH1; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   PhylomeDB; A7THH1; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..704
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408144"
FT   REGION          1..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..60
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..140
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   704 AA;  82349 MW;  E32E44BD28729DF5 CRC64;
     MARHSGTSEG PKKRGRTELR SIRRPNRSQH SKHDQQVVHE SENEDSLESS SDDDEDIAQA
     EAENSDRKEK VYGALLTILN SEHPERKKHK SHSTDFVKEI DEQEEIEQGM ASESEEEDEE
     NDEEESNEGD EEEEEEPTDQ LDTFESHFND VSQDLVDDIS AGFKDKQIKY KSMKYSLDKK
     ESAIFGKPLL LTQQDETIDN PVLTSSYDSY FIKQRLKIQN DLLDSSKENL TPLKKKLLDP
     MFQYKDVLCE YTNYENDEKE YRELYSLHVL NHIYKTRDKI LKDNQRLQEN DDLECLDQGF
     TRPKVLIVVP TRDTAYQVVE TIIEKSGLDQ IDKKGKFKDQ FFDDSLPPTS KPKSFRHVFK
     GNTNDFFVLG MKFTRKAIKL YSNFYQSDII ICSPLGIQMI LENTDKKKRQ DDFLSSIEVM
     IVDQLHSIEY QNISHVYTIL EHINKIPQQQ READFSRIRM WYINDQAKFL RQTMLFTRYI
     SPTANAIING KCHNMAGRWK NNQIISSEDS SIGQLGIKIK QIFQRFDLVG GTVVDESDYR
     FKYFTSVVMQ NIVKSTGYED GILVYIPEYT DYMRLRNYMK EKTTILFSEI NEYSTQKQLD
     SNRSMFQQGR TKVLLYTERL HHYRRYELKG IKSVIFYKPP TNPEFYNEVI RFTAKNAFLG
     KSDINISTIR TVYSKLDGLA LQRIVGSKRA AILCHGQNES YDFK