ID   UTP25_YARLI             Reviewed;         641 AA.
AC   Q6CAC9;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; OrderedLocusNames=YALI0D03960g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CR382130; CAG80571.1; -; Genomic_DNA.
DR   RefSeq; XP_502383.1; XM_502383.1.
DR   AlphaFoldDB; Q6CAC9; -.
DR   STRING; 4952.CAG80571; -.
DR   PRIDE; Q6CAC9; -.
DR   EnsemblFungi; CAG80571; CAG80571; YALI0_D03960g.
DR   GeneID; 2910595; -.
DR   KEGG; yli:YALI0D03960g; -.
DR   VEuPathDB; FungiDB:YALI0_D03960g; -.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; Q6CAC9; -.
DR   OMA; KYFRQTI; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR   GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..641
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408145"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          34..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..86
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   641 AA;  73440 MW;  39D3300FA3458652 CRC64;
     MARSHKVTKP KRQQVDTSGS YNALMVLMGD NVKKAEKRVE EEEPVEQELE EDDIEGAGEE
     EEEVDEEQEE EEDADDAEED AEDDSETDKY DPYKLHFEAE EAKYVSVIKS EEWKTSSEKT
     KIGSQPVRIT YTNLEDADEL LDFSEAQKTE FSKYTVRPRI KDGFKQLNGS LTSVQKAIYP
     SLMAYRDLCY ATSSLSDTEE FSRLVAMHIA QHVVRTAEEV AYNTRILKRN AEEGIHDVEF
     RDQGYTKPRV LVLVPTKNAC FEFMQLLVGA SGVDREDNKA RFNKAFHEAG AVLDTKPEDF
     QKAFKGNTDD MFCLGVKLRN KSIRYYSYFY QADIVFASPL GLKTLVGSEG DSKREFDFLS
     SIEIAYLHET NHMEMQSWDN VLTVLGQTNL LPNESHGCDF SRVKSFYLDG LAKHFRQTIV
     ACQFVTPTIN SVFSNTVNFA GKTKITPIYN GELAVAGMKI RQIFTRFKAL SVSDEIDARF
     KAFVQITLEG MIRSGDYSGT LIYVPTYVEL VRLRNYMDEK NISFGAISEY SSITEVKRHR
     TLFRDGREKI LLYTGRLHHY RRYFVKGVKS VVIYKLPENP AFYRELLLFL THSVDEGTLE
     QSMAKCRALF TIYDLLALER IVGTKRVKTM AKSGESSYEF Y