ID   UTP25_YEAS1             Reviewed;         721 AA.
AC   B3LTT8;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=SCRG_05263;
OS   Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=285006;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RM11-1a;
RG   The Broad Institute Genome Sequencing Platform;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Cuomo C.,
RA   Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M.,
RA   Mauceli E.W., Brockman W., MacCallum I.A., Rounsley S., Young S.K.,
RA   LaButti K., Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   O'Leary S., Kodira C.D., Zeng Q., Yandava C., Alvarado L., Pratt S.,
RA   Kruglyak L.;
RT   "Annotation of the Saccharomyces cerevisiae RM11-1a genome.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with snoRNA U3. Interacts with MPP10, RRp9, UTP8 and
CC       UTP18. Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CH408055; EDV09569.1; -; Genomic_DNA.
DR   AlphaFoldDB; B3LTT8; -.
DR   EnsemblFungi; EDV09569; EDV09569; SCRG_05263.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   Proteomes; UP000008335; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Phosphoprotein; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..721
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408146"
FT   REGION          1..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..70
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..140
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..157
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P40498"
FT   MOD_RES         63
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P40498"
FT   MOD_RES         196
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P40498"
SQ   SEQUENCE   721 AA;  84078 MW;  65E3D7C9E823D428 CRC64;
     MSDSSVREKN DNFRGYRKRG RQELRKIKRS SARTEGGSTE TLEDVAEDID HRSDEDEVSD
     VDSGDDFDIE DEEGKKEKVY DALLTILKSE HPEPKRRRRE ADESNKAPAE VGEDEHENTE
     HGPVDDQLEI ENGLLGNHED DNDDDSSEDE KDIDSEDEQD PFESHFNQVP EKFVDELSNA
     FKTKSVKYKS VKGSLSDSES YIYAKPVVIG EEALVESPYR SSSIYSYFLK QRLKVQNGLL
     DKKTDPLTAL QKKLVDPMFQ YKDILYEYDS YEKDEDEYRD LYALHVLNHI YKTRDRILKN
     NQRLQDNPDT EHLDQGFTRP KVLIVVPTRE VAYRVVDKII SKSGIDQVDK KGKFYDQFRD
     DSLPPKSKPK SFQHIFRGNT NDFFVVGLKF TRKAIKLYSN FYQSDIIVCS PLGIQMILEN
     TDKKKRQDDF LSSIELMVID QLHSIEYQNI SHIFTIFDHL NKIPDQQHEA DFSRIRMWYI
     NEQAKLFRQT MVFTKYISPA ANSLINGRCR NMAGRWKNHK IIGSENSSIG QSGLKIRQIF
     QRFDIIGNSI IEEPDYRFKF FTSVIIPGIV KSTGYEDGIL IYIPDYTDFI RIRNYMKEKT
     TILFGDINEY SSQRQLNANR SLFQQGRLKV MLYTERLHHY RRYEIKGVKS VVFYKPPNNP
     EFYNEVVRFI GKNAFLGNTD LNISTVRCIY SKLDGLSLER IVGTKRAAVL SHAQKEIYEF
     K