ID   UTP25_YEAS8             Reviewed;         721 AA.
AC   C8ZAF8;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=EC1118_1I12_0958g;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA   Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with snoRNA U3. Interacts with MPP10, RRp9, UTP8 and
CC       UTP18. Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; FN393074; CAY80421.1; -; Genomic_DNA.
DR   AlphaFoldDB; C8ZAF8; -.
DR   EnsemblFungi; CAY80421; CAY80421; EC1118_1I12_0958g.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   Proteomes; UP000000286; Chromosome IX, Scaffold EC1118_1I12.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Phosphoprotein; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..721
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408149"
FT   REGION          1..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..70
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..140
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..157
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P40498"
FT   MOD_RES         63
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P40498"
FT   MOD_RES         196
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P40498"
SQ   SEQUENCE   721 AA;  84073 MW;  F9CDAA0950B91B7C CRC64;
     MSDSSVREKN DNFRGYRKRG RQELRKIKRS SARTEGGSTE TLEDVAEDID HRSDEDEVSD
     VDSGDDFDIE DEEGKKEKVY DALLTILKSE HPEPKRRRRE ADESNKAPAE VGEDEHENTE
     HGPVDDQLEI ENGLLGNHED DNDDDSSEDE KDIDSEDEQD PFESHFNQVP EKFVDELSNA
     FKTKSVKYKS VKGSLSDSES YIYAKPVVIG EEALVESPYR SSSIYSYFLK QRLKVQNGLL
     DKKTDPLTAL QKKLVDPMFQ YKDILYEYDS YEKDEDEYRD LYALHVLNHI YKTRDRILKN
     NQRLQDNPDT EHLDQGFTRP KVLIVVPTRE VAYRVVDKII SKSGIDQVDK KGKFYDQFRD
     DSLPPKSKPK SFQHIFRGNT NDFFVVGLKF TRKAIKLYSN FYQSDIIVCS PLGIQMILEN
     TDKKKRQDDF LSSIELMVID QLHSIEYQNI SHIFTIFDHL NKIPDQQHEA DFSRIRMWYI
     NEQAKLFRQT MVFTKYISPA ANSLINGRCR NMAGRWKNHK VIGSENSSIG QSGLKIRQIF
     HRFDIIGNSI IEEPDYRFKF FTSVIIPGIV KSTGYEDGIL IYIPDYTDFI RIRNYMKEKT
     TILFGDINEY SSQRQLNANR SLFQQGRLKV MLYTERLHHY RRYEIKGVKS VVFYKPPNNP
     EFYNEVVRFI GKNAFLGNTD LNISTVRCIY SKLDGLSLER IVGTKRAAVL SHAQKEIYEF
     K