ID   UTP25_ZYGRC             Reviewed;         709 AA.
AC   C5DPB7;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; OrderedLocusNames=ZYRO0A02002g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CU928173; CAR25528.1; -; Genomic_DNA.
DR   RefSeq; XP_002494461.1; XM_002494416.1.
DR   AlphaFoldDB; C5DPB7; -.
DR   STRING; 559307.C5DPB7; -.
DR   PRIDE; C5DPB7; -.
DR   EnsemblFungi; CAR25528; CAR25528; ZYRO0A02002g.
DR   GeneID; 8201590; -.
DR   KEGG; zro:ZYRO0A02002g; -.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; C5DPB7; -.
DR   Proteomes; UP000008536; Chromosome A.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..709
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408150"
FT   REGION          1..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..64
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..104
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..149
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   709 AA;  82399 MW;  860418D4B6691A24 CRC64;
     MVKRTGNGTD AIDGSRKRGR KDLRSIRRAR NDKEPVEEPE IPVASEEDGE LSEDSEEDAT
     NEVQEQEDSK EKAYGALLTI LKSEHPEDRQ RERRKKKQDL QDPSSSDDEL SEDEKGEVEA
     NLVDTPGEEE PQSEEELSEG DEDESEDERD PFESHFNMQS ESIDSLDEAW KQKKIVNKSG
     KIRVDDDESL IYTKTLAGKG QEFELPSHKG HLSSYPLKRK LKIQNNLLES QDDVLTPLQR
     KIVDPIFQYR DLLYEYEDYE QDEDEYRDLY VLHVLNHIYK TRDRILKDNQ RLATNPDGEF
     LDQGFTRPKV LIVAPTRDTA YQIVSKVIEK SGLDQVDKKS KLRDQFFEDV LPPSSKPKSF
     RHTFKGNTND FFVLGVKFTR KAIRLYSNFY QSDLIVCSPL GLQLILENTD RKKRQDDFLS
     SIELMIIDQL NSIEFQNVSH LFTIFAHMNK IPKEQHDTDF GRVRMWYINE QAKLLRQTLI
     FTRYVTPTAN FLLNGKCRNI GGRWKNHHQI TGEQSSVSKL GFRVRQIFQR VDLGGASVVD
     EPDYRFRFFT SVIVPSITKS TGYEDGILLY IPDYADFIRV RNYLKDKTTI LFGDINEYSD
     VRQLTSTRSL FQQGRIKVLL YTERLHHFRR YEIKGVKSVI FYQPPSNPEF YNEVVRYIGK
     SAFLGDTDLN ISTVRCVYSK LDGLALERIV SSKRAAVLTH GQNEIYEFK