UTP4_SCHPO
ID UTP4_SCHPO Reviewed; 710 AA.
AC O60161;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=U3 small nucleolar RNA-associated protein 4;
DE Short=U3 snoRNA-associated protein 4;
DE AltName: Full=U3 protein 4 required for transcription;
GN Name=utp4; ORFNames=SPBC19F5.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAA18650.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Required for optimal pre-ribosomal RNA transcription by RNA polymerase
CC I together with a subset of U3 proteins required for transcription (t-
CC UTPs) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250|UniProtKB:Q06679}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329671; CAA18650.1; -; Genomic_DNA.
DR PIR; T39820; T39820.
DR RefSeq; NP_596540.1; NM_001022461.2.
DR AlphaFoldDB; O60161; -.
DR SMR; O60161; -.
DR BioGRID; 277042; 14.
DR STRING; 4896.SPBC19F5.02c.1; -.
DR MaxQB; O60161; -.
DR PaxDb; O60161; -.
DR EnsemblFungi; SPBC19F5.02c.1; SPBC19F5.02c.1:pep; SPBC19F5.02c.
DR GeneID; 2540514; -.
DR KEGG; spo:SPBC19F5.02c; -.
DR PomBase; SPBC19F5.02c; utp4.
DR VEuPathDB; FungiDB:SPBC19F5.02c; -.
DR eggNOG; KOG2048; Eukaryota.
DR HOGENOM; CLU_002392_2_1_1; -.
DR InParanoid; O60161; -.
DR OMA; PDANWIC; -.
DR PhylomeDB; O60161; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O60161; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR GO; GO:0034455; C:t-UTP complex; ISO:PomBase.
DR GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR046351; UTP4.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR44163; PTHR44163; 1.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50969; SSF50969; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; Transcription; WD repeat.
FT CHAIN 1..710
FT /note="U3 small nucleolar RNA-associated protein 4"
FT /id="PRO_0000307921"
FT REPEAT 11..59
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 64..105
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 108..147
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 154..192
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 199..241
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 290..327
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 328..365
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 488..527
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REPEAT 529..569
FT /note="WD 9"
FT /evidence="ECO:0000255"
SQ SEQUENCE 710 AA; 79121 MW; F7E06170AF75C075 CRC64;
MDIHRCRFID YTPSAITAMA FSHKSGQNDS MPNNLLLAVG RASGNIEIWN PRNDWCLKTV
LYGGVDRSIE GIVWSTGEEE LRLFSIGFST TITEWNLHTG KPLVNQDSNA GAIWSIAICD
ETKTLAVGCD DGSCVLFDIS GGPGVIEFKR VLMRQTSRIL SLDFQTKDHL VGGCADGVIK
VWDLSTPNSA IISRMQVDRA RKGEAALIWA VKSLRDGTIV SADSSGAVKF WNGKFFTLSQ
SFKLHLADAL CLGVSANGDM VFSSGIDRKT IQYSREGGKR EWVSNSFRRF HSHDVRCMAV
FECKSLDVLI SGGMDMMLAV IPVRQFNRKN HRMISAVPQR PRMAVAPKAR LFMLWNDHEV
LLWRIGSPGY RFLLKIVLAD EENISHAAIS PDGELIAISS VLRTKLYQLQ YSDENVKVET
VEDSFLSNIG ASLLSFTVDK NKLILVSNDS EIFLIELSRL DSRQLEVFEL SQPTSKKIAP
RQRSNVSSMC DGICSIAVSS DGDYFAVADT VGNIFCYSLS NLTYSELPRV NTYVRAMAFR
PDVRGRLAVA TAGNQVYEFD VQSRKLSEWS KNNSTNMPKE FSQLLDKAFG AFFDSKHPSR
FWIWSANWVS FFDLNLQLPA PRAAGKRKIE MNATVDGNLN DKKLANANSN GISNYGTGDS
RCFWITHKYR PMLLVGSVGN SELLVVERPI ADMLMSKSMP ASFYEHKFGS
