UTP5_SCHPO
ID UTP5_SCHPO Reviewed; 666 AA.
AC Q9HE11; Q9HGP3;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=U3 small nucleolar RNA-associated protein 5;
DE Short=U3 snoRNA-associated protein 5;
DE AltName: Full=U3 protein 5 required for transcription;
GN Name=utp5; ORFNames=SPAC20H4.01, SPAC631.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Required for optimal pre-ribosomal RNA transcription by RNA polymerase
CC I together with a subset of U3 proteins required for transcription (t-
CC UTPs) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the UTP5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAC05485.1; -; Genomic_DNA.
DR RefSeq; NP_593621.2; NM_001019052.3.
DR AlphaFoldDB; Q9HE11; -.
DR SMR; Q9HE11; -.
DR BioGRID; 279810; 2.
DR STRING; 4896.SPAC20H4.01.1; -.
DR iPTMnet; Q9HE11; -.
DR MaxQB; Q9HE11; -.
DR PaxDb; Q9HE11; -.
DR EnsemblFungi; SPAC20H4.01.1; SPAC20H4.01.1:pep; SPAC20H4.01.
DR GeneID; 2543388; -.
DR KEGG; spo:SPAC20H4.01; -.
DR PomBase; SPAC20H4.01; utp5.
DR VEuPathDB; FungiDB:SPAC20H4.01; -.
DR eggNOG; KOG4547; Eukaryota.
DR HOGENOM; CLU_023936_0_0_1; -.
DR InParanoid; Q9HE11; -.
DR OMA; WVKWCLI; -.
DR PhylomeDB; Q9HE11; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q9HE11; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR GO; GO:0034455; C:t-UTP complex; ISO:PomBase.
DR GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF04003; Utp12; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; Transcription; WD repeat.
FT CHAIN 1..666
FT /note="U3 small nucleolar RNA-associated protein 5"
FT /id="PRO_0000116824"
FT REPEAT 14..56
FT /note="WD 1"
FT REPEAT 60..114
FT /note="WD 2"
FT REPEAT 201..246
FT /note="WD 3"
FT REPEAT 259..301
FT /note="WD 4"
FT REPEAT 316..362
FT /note="WD 5"
FT REPEAT 495..535
FT /note="WD 6"
FT REPEAT 570..609
FT /note="WD 7"
FT REGION 603..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..666
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 666 AA; 73697 MW; 256B109E50655C08 CRC64;
MAVRSRPQLA FQTEKENGIG ITAFNETAKL YANVVEALDA QRLRIFDSVA GSLKTEYILE
KEKVISCIAW EQKPLYASEQ ITTDISGSGE ILVLGTNSGE ILIYSEHLGS LTRTYSFGIL
QKIIGAHVLA NDGFAIDITG KVVCFSVNTG EVRTSFTVPS SSREFSGLYL STVFKNLALA
SSHNIHIVDL NHRNPIDSLT THTSMINSVV FQYLKDENKF YFGVSANQDR FINLYSKELD
GTGEFPTNTV KNVGALVCEN EVKMLSIAYE IENPETGVLA ALTNDGTIEM FENPWLSKLR
QNGTNASSLS HRRKLLTSHS TLKICFCRSR GDPPIVLESI AFESTDSLTV VWKESTRTVF
ETVPWRILSS QATNGLIELV RSKTRLTSKN KTVSNVYDES NATISSGVMQ KDLRKTEEIG
SAEAMEGEEQ EPSLAERLQN LTKLDQQAQA LSTQISASTS LSTVLTQALK TNDQSLLESC
FNNNNVETID TTIRRLDPSL APILLDKLAE KLALRPMRAD VLMVWIRCTL ITHGGHLVLV
DDLKHKLANL HSILEDRASK YSSMLALQGK LDLVLSQIAF RKAGGSKDNA EDEEPISIYY
EGYEESMDEA SSTGDEGYSS DDSVDNEMYS DEENSSKGAF PDEENENREL SEDYSGDESL
ENSESE
