ID   UTP6_DICDI              Reviewed;         609 AA.
AC   Q54WN5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 6 homolog;
GN   Name=utp6; ORFNames=DDB_G0279601;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16512674; DOI=10.1021/pr050350q;
RA   Reinders Y., Schulz I., Graef R., Sickmann A.;
RT   "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT   by comparative proteomic approaches.";
RL   J. Proteome Res. 5:589-598(2006).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP6 family. {ECO:0000305}.
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DR   EMBL; AAFI02000031; EAL67739.1; -; Genomic_DNA.
DR   RefSeq; XP_641682.1; XM_636590.1.
DR   AlphaFoldDB; Q54WN5; -.
DR   SMR; Q54WN5; -.
DR   IntAct; Q54WN5; 1.
DR   STRING; 44689.DDB0233969; -.
DR   PaxDb; Q54WN5; -.
DR   EnsemblProtists; EAL67739; EAL67739; DDB_G0279601.
DR   GeneID; 8622090; -.
DR   KEGG; ddi:DDB_G0279601; -.
DR   dictyBase; DDB_G0279601; utp6.
DR   eggNOG; KOG2396; Eukaryota.
DR   HOGENOM; CLU_479153_0_0_1; -.
DR   InParanoid; Q54WN5; -.
DR   OMA; CKQWNAK; -.
DR   PhylomeDB; Q54WN5; -.
DR   Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q54WN5; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; ISS:dictyBase.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; ISS:dictyBase.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR013949; Utp6.
DR   PANTHER; PTHR23271; PTHR23271; 1.
DR   Pfam; PF08640; U3_assoc_6; 1.
DR   SMART; SM00386; HAT; 4.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Repeat; rRNA processing.
FT   CHAIN           1..609
FT                   /note="U3 small nucleolar RNA-associated protein 6 homolog"
FT                   /id="PRO_0000327717"
FT   REPEAT          84..116
FT                   /note="HAT 1"
FT   REPEAT          118..150
FT                   /note="HAT 2"
FT   REPEAT          511..540
FT                   /note="HAT 3"
FT   REPEAT          544..579
FT                   /note="HAT 4"
SQ   SEQUENCE   609 AA;  71117 MW;  84F168E744B5C8D0 CRC64;
     MDRVNFSIDQ LLEETSKLVS LGIISKQECK DIMKKREYHE IKIFNRNSHK SDFLTYIKYE
     LELDRLFHKR GKAKNIEFDY RLRSALRHAI ILFGSATKKF PKDEALWINA LNIRMKRASK
     EGTGRLFSIA LSNLPRSAKL WKLAATFEFE VNKNIQNARN LIQAGIQFNK TDKSLWHYFF
     LMELTYISLL FSDITFIDKK IEEEEEEAIK LNLDSLRKSE KIEKDEFITF GKEILSADKL
     KQSSLIRGQI AQIVFRKAIK SSIGQDFDFR KHFYKIASKF LDIGKDSENP MGAGELLQKE
     ILESLVTDFP NDDKTYIFLA SIEQSKSSEP SLLKRLNNST KILNQGLTII KSESYLFNYI
     HFIRQIIVDI KLKENKLIEN ITDILLKAYK YSIDNNILKE SGYQYYIELL LELGKTNDAI
     KVSEESVKLF KNSNQLWNQR INLLIKNEMV VKLFDNLSNN NEYNNIDKCF EMAVKNCTSS
     TTSTTSSTST SSSSNLFIEY FKYQVVFKFD KDYKKIVDLF EKLLKQLDEF YQKCILYEEE
     RIEKNINDIR SLYEKCLSIK EISSKDVDVW LNYRNFELKS AGDIERANTI ATRGKKSLAD
     PLPLLSQLQ