UTP6_MOUSE
ID UTP6_MOUSE Reviewed; 597 AA.
AC Q8VCY6; Q8CH76;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=U3 small nucleolar RNA-associated protein 6 homolog;
DE AltName: Full=Multiple hat domains protein;
GN Name=Utp6; Synonyms=Mhat;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ICR;
RA Agarwala K.L., Suzuki T., Tsutsumi Y., Amano K., Yamakawa K.;
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Eye, Mammary tumor, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UTP6 family. {ECO:0000305}.
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DR EMBL; AF334387; AAO15383.1; -; mRNA.
DR EMBL; AK029151; BAC26328.1; -; mRNA.
DR EMBL; AK084976; BAC39327.1; -; mRNA.
DR EMBL; AL591113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC018250; AAH18250.1; -; mRNA.
DR EMBL; BC024850; AAH24850.1; -; mRNA.
DR EMBL; BC023920; AAH23920.1; -; mRNA.
DR CCDS; CCDS25124.1; -.
DR RefSeq; NP_659075.1; NM_144826.3.
DR AlphaFoldDB; Q8VCY6; -.
DR SMR; Q8VCY6; -.
DR BioGRID; 229829; 4.
DR IntAct; Q8VCY6; 1.
DR STRING; 10090.ENSMUSP00000046643; -.
DR iPTMnet; Q8VCY6; -.
DR PhosphoSitePlus; Q8VCY6; -.
DR EPD; Q8VCY6; -.
DR MaxQB; Q8VCY6; -.
DR PaxDb; Q8VCY6; -.
DR PeptideAtlas; Q8VCY6; -.
DR PRIDE; Q8VCY6; -.
DR ProteomicsDB; 297952; -.
DR Antibodypedia; 15269; 145 antibodies from 25 providers.
DR DNASU; 216987; -.
DR Ensembl; ENSMUST00000043152; ENSMUSP00000046643; ENSMUSG00000035575.
DR Ensembl; ENSMUST00000108241; ENSMUSP00000103876; ENSMUSG00000035575.
DR GeneID; 216987; -.
DR KEGG; mmu:216987; -.
DR UCSC; uc007klb.1; mouse.
DR CTD; 55813; -.
DR MGI; MGI:2445193; Utp6.
DR VEuPathDB; HostDB:ENSMUSG00000035575; -.
DR eggNOG; KOG2396; Eukaryota.
DR GeneTree; ENSGT00390000016493; -.
DR HOGENOM; CLU_026025_2_0_1; -.
DR InParanoid; Q8VCY6; -.
DR OMA; CKQWNAK; -.
DR OrthoDB; 367609at2759; -.
DR PhylomeDB; Q8VCY6; -.
DR TreeFam; TF323957; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 216987; 26 hits in 72 CRISPR screens.
DR ChiTaRS; Utp6; mouse.
DR PRO; PR:Q8VCY6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8VCY6; protein.
DR Bgee; ENSMUSG00000035575; Expressed in indifferent gonad and 260 other tissues.
DR Genevisible; Q8VCY6; MM.
DR GO; GO:0005694; C:chromosome; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013949; Utp6.
DR PANTHER; PTHR23271; PTHR23271; 1.
DR Pfam; PF08640; U3_assoc_6; 1.
DR SMART; SM00386; HAT; 6.
DR SUPFAM; SSF48452; SSF48452; 2.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repeat; rRNA processing.
FT CHAIN 1..597
FT /note="U3 small nucleolar RNA-associated protein 6 homolog"
FT /id="PRO_0000239466"
FT REPEAT 121..153
FT /note="HAT 1"
FT REPEAT 156..188
FT /note="HAT 2"
FT REPEAT 304..335
FT /note="HAT 3"
FT REPEAT 488..520
FT /note="HAT 4"
FT REPEAT 524..557
FT /note="HAT 5"
FT CONFLICT 524
FT /note="P -> S (in Ref. 1; AAO15383)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 597 AA; 70429 MW; AC8D5282DA3C1C0E CRC64;
MAEIIQERIE DRIPELEQLE RIGLFSHAEI KAIIKKASDL EYKIHRRTLL KEDFINYVQY
EINLLELIQR RRARIKYSFK KDEIEYSMVH RVQGVFGRAS AKWKDDVQLW LSYIVFCKKW
GTKTHLSKIF SAMLAIHSNK PALWIMAAKW EMEDRLSSES ARQLFLRALR FHPECPKLYQ
EYFRMELMHA EKLRKEKQEF EKAAMDMGDF DHPEEILKGE LARIIYKNSI SKIKGAEFHV
SLLAIAQLFD FAKDLQKEIY DDLQALHTDD PLTWDYVARR ELEIESQPGE EQPVSKQAKA
VEMGRREERC CAVYEEAVKA LPTEAMWKCY ITFCLERFSK KTSSVPLRGQ RLERTMLAFR
KAHELKLLSE VQYKQWIDLL LRQDLFKEAL QVAEAGTELF KDSVTMWQTK LQVLIDSKSP
DVEMRFEEAF AHLKPQVCLP LWISWAEWSE SAKSQEDTEA IFKKAIIAVT GASSVTLKEK
YLDWAYRSGG YKKARAVFKS LQESRPFSVE FFRKMMQFEK EQEPCKMVNL REYYERALRE
FGTSDSDLWM DYIKEELNHP FGKPENCGQI YWRAMKMLQG QSAELFVAKH AMHQAGH
