ID   UTP6_SCHPO              Reviewed;         488 AA.
AC   O60188;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 6;
DE            Short=U3 snoRNA-associated protein 6;
GN   Name=utp6; ORFNames=SPBC244.02c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Component of the SSU processome, a pre-ribosomal particle
CC       required for the maturation of the 18S rRNA from the 35S pre-rRNA
CC       precursor. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome,
CC       composed of the 35S pre-rRNA precursor, the U3 snoRNA, and at least 40
CC       protein subunits. Interacts with U3 snoRNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP6 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA19317.1; -; Genomic_DNA.
DR   PIR; T39963; T39963.
DR   RefSeq; NP_596813.1; NM_001023833.2.
DR   AlphaFoldDB; O60188; -.
DR   SMR; O60188; -.
DR   BioGRID; 277176; 1.
DR   STRING; 4896.SPBC244.02c.1; -.
DR   iPTMnet; O60188; -.
DR   MaxQB; O60188; -.
DR   PaxDb; O60188; -.
DR   PRIDE; O60188; -.
DR   EnsemblFungi; SPBC244.02c.1; SPBC244.02c.1:pep; SPBC244.02c.
DR   GeneID; 2540651; -.
DR   KEGG; spo:SPBC244.02c; -.
DR   PomBase; SPBC244.02c; utp6.
DR   VEuPathDB; FungiDB:SPBC244.02c; -.
DR   eggNOG; KOG2396; Eukaryota.
DR   HOGENOM; CLU_026025_3_0_1; -.
DR   InParanoid; O60188; -.
DR   OMA; FLSYIQY; -.
DR   PhylomeDB; O60188; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:O60188; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0032153; C:cell division site; HDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR   GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISO:PomBase.
DR   GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISO:PomBase.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR013949; Utp6.
DR   PANTHER; PTHR23271; PTHR23271; 1.
DR   Pfam; PF08640; U3_assoc_6; 1.
DR   SMART; SM00386; HAT; 4.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..488
FT                   /note="U3 small nucleolar RNA-associated protein 6"
FT                   /id="PRO_0000374010"
FT   REPEAT          31..63
FT                   /note="HAT 1"
FT   REPEAT          87..119
FT                   /note="HAT 2"
FT   REPEAT          121..153
FT                   /note="HAT 3"
FT   REPEAT          156..188
FT                   /note="HAT 4"
SQ   SEQUENCE   488 AA;  55645 MW;  2EBFCC1D4F3E55EC CRC64;
     MAEKVQYYME QSVPELEDLL EKNIFNRDEI NNIIKTRRVF EEKLARRQVK LNDFLSYIQY
     EINLETLRAK RHKRLNITGK ITISDYAGPR KVLFLFLRAT NKFFGDVTLW LDYIHYAQKI
     KAVNIVGKIC VAALQKHPNN AELWVVACDH EFSINANVSA ARALMNRALR LNQENPVIWA
     AYFRLELSYM TKLFARSQIL TGNISSKTEN ITNGVSEDTI GSLSSDTIQL PMVSMEEFLG
     SSSSEVRKND SDLNISDDIG NISSKEQQTQ KFANVLLQII LNSRKNLSLQ NYVGFFVSVL
     DALFECFDVP VVQYMYQENI IGICNEHFEH FKNESGEIYG VLLHRWCFLE IFIKLRGAYP
     SNDSGISGKG IFGLKKNDPR ITSMVLTDPG FVDDLQAIVE KYQSISSDFQ IPFKTKKIFY
     SFFVKTLHAI SSSSAAESSI ALALHMLVIN AFQSMEKLKI LTFDDSLQEI YKEAQIQSGT
     FMSNATLS