UTP7_SCHPO
ID UTP7_SCHPO Reviewed; 520 AA.
AC Q9P4X3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 140.
DE RecName: Full=Probable U3 small nucleolar RNA-associated protein 7;
DE Short=U3 snoRNA-associated protein 7;
DE AltName: Full=U three protein 7;
GN Name=utp7; ORFNames=SPAC959.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329670; CAB93010.1; -; Genomic_DNA.
DR RefSeq; NP_594170.1; NM_001019594.2.
DR AlphaFoldDB; Q9P4X3; -.
DR SMR; Q9P4X3; -.
DR BioGRID; 279904; 8.
DR STRING; 4896.SPAC959.03c.1; -.
DR MaxQB; Q9P4X3; -.
DR PaxDb; Q9P4X3; -.
DR EnsemblFungi; SPAC959.03c.1; SPAC959.03c.1:pep; SPAC959.03c.
DR GeneID; 2543484; -.
DR KEGG; spo:SPAC959.03c; -.
DR PomBase; SPAC959.03c; utp7.
DR VEuPathDB; FungiDB:SPAC959.03c; -.
DR eggNOG; KOG1272; Eukaryota.
DR HOGENOM; CLU_022996_1_1_1; -.
DR InParanoid; Q9P4X3; -.
DR OMA; KYTFIYD; -.
DR PhylomeDB; Q9P4X3; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q9P4X3; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISO:PomBase.
DR GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR012952; BING4_C_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR040315; WDR46/Utp7.
DR PANTHER; PTHR14085; PTHR14085; 1.
DR Pfam; PF08149; BING4CT; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01033; BING4CT; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; WD repeat.
FT CHAIN 1..520
FT /note="Probable U3 small nucleolar RNA-associated protein
FT 7"
FT /id="PRO_0000316546"
FT REPEAT 99..140
FT /note="WD 1"
FT REPEAT 142..179
FT /note="WD 2"
FT REPEAT 218..260
FT /note="WD 3"
FT REPEAT 263..302
FT /note="WD 4"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 59758 MW; 965914DA5D978EAA CRC64;
MSAQKLNLED VNASTKKYSR GRKLNPKKIK DKKLRSNIQK IEERIENVES SLAKTEILHE
DNPGLLEAEG LERTYKFRQD QLAPNVALET ATKSFSLDLD KFGGYSFDYT RDGRMILLGG
RKGHISAFDW RTGKLLTELH LRETVRDVKW FHNHQYFAVA QKKYVYVYDN MGTEIHCLKR
HIEVNALDFL PYHLLLTSIG NAGYLKYQDV STGQLVAEHR TGMGASHVLH QNPHNAVEHV
GHANGQVTLW SPSSTTPLVK MLTHRGPVRD LAVNRDGRYM VTAGADSLLK VWDLRTYKEL
HSYYTPTPAQ RLTLSDRGLL AVGWGPHATI WKDALRTKQN FPYMNHLLPS SSVVDLHYCP
YEDILGIGHA KGFESIIVPG SGEPNYDSYE NDPFASRKQR QETEVRQLLE KLRPEMISLN
ADFIGNVDRA APSLRKAEAE EEKPPEEKWV PKAKARGKNS ALRRYLRKHA RNVVDQRRLK
VEKSLEIEKK MRAQRVRREQ KLPEEREKWG YALSRFVSKK
