UTP7_YEAST
ID UTP7_YEAST Reviewed; 554 AA.
AC P40055; D3DLY9;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=U3 small nucleolar RNA-associated protein 7;
DE Short=U3 snoRNA-associated protein 7;
DE AltName: Full=U three protein 7;
GN Name=UTP7; Synonyms=KRE31; OrderedLocusNames=YER082C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU
RP PROCESSOME BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=12068309; DOI=10.1038/nature00769;
RA Dragon F., Gallagher J.E.G., Compagnone-Post P.A., Mitchell B.M.,
RA Porwancher K.A., Wehner K.A., Wormsley S., Settlage R.E., Shabanowitz J.,
RA Osheim Y., Beyer A.L., Hunt D.F., Baserga S.J.;
RT "A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA
RT biogenesis.";
RL Nature 417:967-970(2002).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC {ECO:0000269|PubMed:12068309}.
CC -!- SUBUNIT: Interacts with snoRNA U3. Interacts with MPP10. Component of
CC the ribosomal small subunit (SSU) processome composed of at least 40
CC protein subunits and snoRNA U3. {ECO:0000269|PubMed:12068309}.
CC -!- INTERACTION:
CC P40055; P42945: UTP10; NbExp=6; IntAct=EBI-22597, EBI-1884;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12068309}.
CC -!- MISCELLANEOUS: Present with 5800 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U18839; AAB64637.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07743.1; -; Genomic_DNA.
DR PIR; S50585; S50585.
DR RefSeq; NP_011005.1; NM_001178973.1.
DR PDB; 5WLC; EM; 3.80 A; LW=1-554.
DR PDB; 6KE6; EM; 3.40 A; 5C=1-554.
DR PDB; 6LQP; EM; 3.20 A; 5C=1-554.
DR PDB; 6LQQ; EM; 4.10 A; 5C=1-554.
DR PDB; 6LQR; EM; 8.60 A; 5C=1-554.
DR PDB; 6LQS; EM; 3.80 A; 5C=1-554.
DR PDB; 6LQT; EM; 4.90 A; 5C=1-554.
DR PDB; 6LQU; EM; 3.70 A; 5C=1-554.
DR PDB; 6LQV; EM; 4.80 A; 5C=1-554.
DR PDB; 6ND4; EM; 4.30 A; W=1-554.
DR PDB; 6ZQA; EM; 4.40 A; UG=1-554.
DR PDB; 6ZQB; EM; 3.90 A; UG=1-554.
DR PDB; 6ZQC; EM; 3.80 A; UG=1-554.
DR PDB; 6ZQD; EM; 3.80 A; UG=1-554.
DR PDB; 7AJT; EM; 4.60 A; UG=1-554.
DR PDB; 7AJU; EM; 3.80 A; UG=1-554.
DR PDB; 7D4I; EM; 4.00 A; 5C=1-554.
DR PDB; 7D5S; EM; 4.60 A; 5C=1-554.
DR PDB; 7D5T; EM; 6.00 A; 5C=1-554.
DR PDB; 7D63; EM; 12.30 A; 5C=1-554.
DR PDBsum; 5WLC; -.
DR PDBsum; 6KE6; -.
DR PDBsum; 6LQP; -.
DR PDBsum; 6LQQ; -.
DR PDBsum; 6LQR; -.
DR PDBsum; 6LQS; -.
DR PDBsum; 6LQT; -.
DR PDBsum; 6LQU; -.
DR PDBsum; 6LQV; -.
DR PDBsum; 6ND4; -.
DR PDBsum; 6ZQA; -.
DR PDBsum; 6ZQB; -.
DR PDBsum; 6ZQC; -.
DR PDBsum; 6ZQD; -.
DR PDBsum; 7AJT; -.
DR PDBsum; 7AJU; -.
DR PDBsum; 7D4I; -.
DR PDBsum; 7D5S; -.
DR PDBsum; 7D5T; -.
DR PDBsum; 7D63; -.
DR AlphaFoldDB; P40055; -.
DR SMR; P40055; -.
DR BioGRID; 36827; 268.
DR ComplexPortal; CPX-1604; Small ribosomal subunit processome, variant 1.
DR ComplexPortal; CPX-1607; Small ribosomal subunit processome, variant 2.
DR ComplexPortal; CPX-1608; Small ribosomal subunit processome, variant 3.
DR DIP; DIP-5398N; -.
DR IntAct; P40055; 80.
DR MINT; P40055; -.
DR STRING; 4932.YER082C; -.
DR MaxQB; P40055; -.
DR PaxDb; P40055; -.
DR PRIDE; P40055; -.
DR EnsemblFungi; YER082C_mRNA; YER082C; YER082C.
DR GeneID; 856815; -.
DR KEGG; sce:YER082C; -.
DR SGD; S000000884; UTP7.
DR VEuPathDB; FungiDB:YER082C; -.
DR eggNOG; KOG1272; Eukaryota.
DR GeneTree; ENSGT00390000007075; -.
DR HOGENOM; CLU_022996_1_1_1; -.
DR InParanoid; P40055; -.
DR OMA; KYTFIYD; -.
DR BioCyc; YEAST:G3O-30252-MON; -.
DR Reactome; R-SCE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:P40055; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P40055; protein.
DR GO; GO:0030686; C:90S preribosome; HDA:SGD.
DR GO; GO:0005730; C:nucleolus; IDA:SGD.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IDA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IDA:SGD.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
DR GO; GO:0030490; P:maturation of SSU-rRNA; IC:ComplexPortal.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR012952; BING4_C_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR040315; WDR46/Utp7.
DR PANTHER; PTHR14085; PTHR14085; 1.
DR Pfam; PF08149; BING4CT; 1.
DR SMART; SM01033; BING4CT; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; WD repeat.
FT CHAIN 1..554
FT /note="U3 small nucleolar RNA-associated protein 7"
FT /id="PRO_0000051319"
FT REPEAT 108..149
FT /note="WD 1"
FT REPEAT 230..269
FT /note="WD 2"
FT REPEAT 272..311
FT /note="WD 3"
FT REPEAT 314..351
FT /note="WD 4"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 62317 MW; A254AD9AC1142AA5 CRC64;
MGHKKNGHRR QIKERENQNK FERSTYTNNA KNNHTQTKDK KLRAGLKKID EQYKKAVSSA
AATDYLLPES NGYLEPENEL EKTFKVQQSE IKSSVDVSTA NKALDLSLKE FGPYHIKYAK
NGTHLLITGR KGHVASMDWR KGQLRAELFL NETCHSATYL QNEQYFAVAQ KKYTFIYDHE
GTELHRLKQH IEARHLDFLP YHYLLVTAGE TGWLKYHDVS TGQLVSELRT KAGPTMAMAQ
NPWNAVMHLG HSNGTVSLWS PSMPEPLVKL LSARGPVNSI AIDRSGYYMA TTGADRSMKI
WDIRNFKQLH SVESLPTPGT NVSISDTGLL ALSRGPHVTL WKDALKLSGD SKPCFGSMGG
NPHRNTPYMS HLFAGNKVEN LGFVPFEDLL GVGHQTGITN LIVPGAGEAN YDALELNPFE
TKKQRQEQEV RTLLNKLPAD TITLDPNSIG SVDKRSSTIR LNAKDLAQTT MDANNKAKTN
SDIPDVKPDV KGKNSGLRSF LRKKTQNVID ERKLRVQKQL DKEKNIRKRN HQIKQGLISE
DHKDVIEEAL SRFG
