UTR2_ARATH
ID UTR2_ARATH Reviewed; 345 AA.
AC Q29Q28; F4JMR0; O82750;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=UDP-galactose/UDP-glucose transporter 2 {ECO:0000303|PubMed:12042319};
DE Short=AtUTr2 {ECO:0000303|PubMed:12042319};
GN Name=UTR2 {ECO:0000303|PubMed:12042319};
GN OrderedLocusNames=At4g23010 {ECO:0000312|Araport:AT4G23010};
GN ORFNames=F7H19.200 {ECO:0000312|EMBL:CAA19817.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=15891899; DOI=10.1007/s00425-005-1557-x;
RA Norambuena L., Nilo R., Handford M., Reyes F., Marchant L., Meisel L.,
RA Orellana A.;
RT "AtUTr2 is an Arabidopsis thaliana nucleotide sugar transporter located in
RT the Golgi apparatus capable of transporting UDP-galactose.";
RL Planta 222:521-529(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12042319; DOI=10.1074/jbc.m204081200;
RA Norambuena L., Marchant L., Berninsone P., Hirschberg C.B., Silva H.,
RA Orellana A.;
RT "Transport of UDP-galactose in plants. Identification and functional
RT characterization of AtUTr1, an Arabidopsis thaliana UDP-galactose/UDP-
RT glucose transporter.";
RL J. Biol. Chem. 277:32923-32929(2002).
RN [7]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=15456736; DOI=10.1093/glycob/cwh159;
RA Bakker H., Routier F., Oelmann S., Jordi W., Lommen A., Gerardy-Schahn R.,
RA Bosch D.;
RT "Molecular cloning of two Arabidopsis UDP-galactose transporters by
RT complementation of a deficient Chinese hamster ovary cell line.";
RL Glycobiology 15:193-201(2005).
RN [8]
RP GENE FAMILY.
RX PubMed=25053812; DOI=10.1073/pnas.1406073111;
RA Rautengarten C., Ebert B., Moreno I., Temple H., Herter T., Link B.,
RA Donas-Cofre D., Moreno A., Saez-Aguayo S., Blanco F., Mortimer J.C.,
RA Schultink A., Reiter W.D., Dupree P., Pauly M., Heazlewood J.L.,
RA Scheller H.V., Orellana A.;
RT "The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter
RT family of Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:11563-11568(2014).
CC -!- FUNCTION: Sugar transporter involved in the transport of UDP-galactose
CC form the cytoplasm into the Golgi apparatus.
CC {ECO:0000269|PubMed:15891899}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:15891899}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15891899}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q29Q28-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q29Q28-2; Sequence=VSP_042441;
CC Name=3;
CC IsoId=Q29Q28-3; Sequence=VSP_042442;
CC -!- TISSUE SPECIFICITY: Mostly expressed in roots, and, to a lower extent,
CC in seedlings, shoots, leaves and flowers.
CC {ECO:0000269|PubMed:15891899}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. UDP-
CC galactose:UMP antiporter (TC 2.A.7.11) subfamily. {ECO:0000305}.
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DR EMBL; DQ015901; AAY79163.1; -; mRNA.
DR EMBL; AL031018; CAA19817.1; -; Genomic_DNA.
DR EMBL; AL161558; CAB79256.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84692.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84693.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84694.1; -; Genomic_DNA.
DR EMBL; BT024728; ABD59066.1; -; mRNA.
DR EMBL; AK227353; BAE99363.1; -; mRNA.
DR PIR; T05133; T05133.
DR RefSeq; NP_001078433.1; NM_001084964.1. [Q29Q28-2]
DR RefSeq; NP_001190806.1; NM_001203877.1. [Q29Q28-3]
DR RefSeq; NP_194032.2; NM_118430.5. [Q29Q28-1]
DR AlphaFoldDB; Q29Q28; -.
DR SMR; Q29Q28; -.
DR BioGRID; 13689; 89.
DR IntAct; Q29Q28; 89.
DR PRIDE; Q29Q28; -.
DR ProteomicsDB; 228538; -. [Q29Q28-1]
DR EnsemblPlants; AT4G23010.1; AT4G23010.1; AT4G23010. [Q29Q28-1]
DR EnsemblPlants; AT4G23010.2; AT4G23010.2; AT4G23010. [Q29Q28-2]
DR EnsemblPlants; AT4G23010.3; AT4G23010.3; AT4G23010. [Q29Q28-3]
DR GeneID; 828400; -.
DR Gramene; AT4G23010.1; AT4G23010.1; AT4G23010. [Q29Q28-1]
DR Gramene; AT4G23010.2; AT4G23010.2; AT4G23010. [Q29Q28-2]
DR Gramene; AT4G23010.3; AT4G23010.3; AT4G23010. [Q29Q28-3]
DR KEGG; ath:AT4G23010; -.
DR Araport; AT4G23010; -.
DR TAIR; locus:2127163; AT4G23010.
DR InParanoid; Q29Q28; -.
DR OMA; WPACAQH; -.
DR OrthoDB; 1116466at2759; -.
DR PhylomeDB; Q29Q28; -.
DR PRO; PR:Q29Q28; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q29Q28; baseline and differential.
DR Genevisible; Q29Q28; AT.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IDA:UniProtKB.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0072334; P:UDP-galactose transmembrane transport; IDA:UniProtKB.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Antiport; Golgi apparatus; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..345
FT /note="UDP-galactose/UDP-glucose transporter 2"
FT /id="PRO_0000415961"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 326..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 199
FT /note="Q -> QARKLKKTRLTLVMCVVQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15891899"
FT /id="VSP_042441"
FT VAR_SEQ 233
FT /note="Q -> QSSILSESDKEWNLLFGFESTSIDLTRFMIQTGVGLSLEKKSKFVGF
FT L (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_042442"
SQ SEQUENCE 345 AA; 38373 MW; 0FBD4451A5A493B4 CRC64;
MKEEQTRSLF GISLSDKPTW QQFLICTSGF FFGYLVNGVC EEYVYNRLQF SFGWYFTFIQ
GFVYLFLIYL QGFTTKHIVN PMRTYVKLSA VLMGSHGLTK GSLAYLNYPA QIMFKSTKVL
PVMIMGAFIP GLRRKYPVHE YISAFLLVLG LILFTLADAQ MSPNFSMIGI MMITGALIMD
AFLGNLQEAI FTMNPETTQM EMLFCSTVVG LPFLFVPMVL TGEVFRAWTA CAQHPYVYGV
LVFEAMATFI GQVSVLSLIA LFGAATTALI TTARKGVTLL LSYLIFTKPL TEQHGSGLLL
IAMGIVLKMV PMDSKAPAKI PARPAVRIAG GDGDREEDEE RKSLV
