UTR4_ARATH
ID UTR4_ARATH Reviewed; 349 AA.
AC Q9LDX3;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=UDP-galactose/UDP-glucose transporter 4 {ECO:0000303|PubMed:12042319};
DE Short=AtUTr4 {ECO:0000303|PubMed:12042319};
GN Name=UTR4 {ECO:0000303|PubMed:12042319};
GN OrderedLocusNames=At1g12600 {ECO:0000312|Araport:AT1G12600};
GN ORFNames=F5O11.33 {ECO:0000312|EMBL:AAF79647.1},
GN T12C24.13 {ECO:0000312|EMBL:AAF88097.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=16244158; DOI=10.1104/pp.105.063479;
RA Xiao Y.-L., Smith S.R., Ishmael N., Redman J.C., Kumar N., Monaghan E.L.,
RA Ayele M., Haas B.J., Wu H.C., Town C.D.;
RT "Analysis of the cDNAs of hypothetical genes on Arabidopsis chromosome 2
RT reveals numerous transcript variants.";
RL Plant Physiol. 139:1323-1337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12042319; DOI=10.1074/jbc.m204081200;
RA Norambuena L., Marchant L., Berninsone P., Hirschberg C.B., Silva H.,
RA Orellana A.;
RT "Transport of UDP-galactose in plants. Identification and functional
RT characterization of AtUTr1, an Arabidopsis thaliana UDP-galactose/UDP-
RT glucose transporter.";
RL J. Biol. Chem. 277:32923-32929(2002).
RN [6]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=15456736; DOI=10.1093/glycob/cwh159;
RA Bakker H., Routier F., Oelmann S., Jordi W., Lommen A., Gerardy-Schahn R.,
RA Bosch D.;
RT "Molecular cloning of two Arabidopsis UDP-galactose transporters by
RT complementation of a deficient Chinese hamster ovary cell line.";
RL Glycobiology 15:193-201(2005).
RN [7]
RP GENE FAMILY.
RX PubMed=25053812; DOI=10.1073/pnas.1406073111;
RA Rautengarten C., Ebert B., Moreno I., Temple H., Herter T., Link B.,
RA Donas-Cofre D., Moreno A., Saez-Aguayo S., Blanco F., Mortimer J.C.,
RA Schultink A., Reiter W.D., Dupree P., Pauly M., Heazlewood J.L.,
RA Scheller H.V., Orellana A.;
RT "The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter
RT family of Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:11563-11568(2014).
CC -!- FUNCTION: Sugar transporter involved in the transport of nucleotide-
CC sugars from cytoplasm into the Golgi and/or the endoplasmic reticulum.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. UDP-
CC galactose:UMP antiporter (TC 2.A.7.11) subfamily. {ECO:0000305}.
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DR EMBL; AC025416; AAF79647.1; -; Genomic_DNA.
DR EMBL; AC025417; AAF88097.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28900.1; -; Genomic_DNA.
DR EMBL; AY800577; AAV68813.1; -; mRNA.
DR EMBL; AY924666; AAX23741.1; -; mRNA.
DR RefSeq; NP_172720.1; NM_101130.3.
DR AlphaFoldDB; Q9LDX3; -.
DR SMR; Q9LDX3; -.
DR STRING; 3702.AT1G12600.1; -.
DR PaxDb; Q9LDX3; -.
DR PRIDE; Q9LDX3; -.
DR ProteomicsDB; 228539; -.
DR EnsemblPlants; AT1G12600.1; AT1G12600.1; AT1G12600.
DR GeneID; 837816; -.
DR Gramene; AT1G12600.1; AT1G12600.1; AT1G12600.
DR KEGG; ath:AT1G12600; -.
DR Araport; AT1G12600; -.
DR TAIR; locus:2195032; AT1G12600.
DR eggNOG; KOG1582; Eukaryota.
DR HOGENOM; CLU_036019_2_1_1; -.
DR InParanoid; Q9LDX3; -.
DR OMA; FFRIRTP; -.
DR OrthoDB; 1116466at2759; -.
DR PhylomeDB; Q9LDX3; -.
DR PRO; PR:Q9LDX3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LDX3; baseline and differential.
DR Genevisible; Q9LDX3; AT.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 2: Evidence at transcript level;
KW Antiport; Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..349
FT /note="UDP-galactose/UDP-glucose transporter 4"
FT /id="PRO_0000415963"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 316..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 349 AA; 38944 MW; 44C33DFCDAB09C41 CRC64;
MKTNSEEQMI KLFGIPLSDK PRWQQFLICS SGFFFGYLVN GICEEYVYNR LKFSYGWYFT
FAQGLVYIAL IYMYGFRTKQ MVNPWKTYVK LSGVLMGSHG LTKGSLAYLN YPAQIMFKST
KVLPVMVMGA FIPGLRRKYP VHEYISAMLL VIGLILFTLA DAHTSPNFSI IGVMMISGAL
IMDAFLGNLQ EAIFTMNPET TQMEMLFCST VVGLPFLLAP MILTGELFTA WNSCAQHPYV
YGVLVFEAMA TFIGQVSVLS LIALFGAATT AMITTARKAV TLLLSYLIFT KPLTEQHGTG
LLLIFMGIIL KMVPDPNPNP KSSGSGQTPG KLERVKFEKE DDEESRPLV
