UTR5B_ARATH
ID UTR5B_ARATH Reviewed; 344 AA.
AC Q6NMB6; Q682A6; Q9FN90;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=UDP-galactose/UDP-glucose transporter 5B {ECO:0000305};
DE Short=AtUTr5B {ECO:0000305};
GN Name=UTR5B {ECO:0000305};
GN OrderedLocusNames=At5g59740 {ECO:0000312|Araport:AT5G59740};
GN ORFNames=MTH12.11 {ECO:0000312|EMBL:BAB09511.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12042319; DOI=10.1074/jbc.m204081200;
RA Norambuena L., Marchant L., Berninsone P., Hirschberg C.B., Silva H.,
RA Orellana A.;
RT "Transport of UDP-galactose in plants. Identification and functional
RT characterization of AtUTr1, an Arabidopsis thaliana UDP-galactose/UDP-
RT glucose transporter.";
RL J. Biol. Chem. 277:32923-32929(2002).
RN [6]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=15456736; DOI=10.1093/glycob/cwh159;
RA Bakker H., Routier F., Oelmann S., Jordi W., Lommen A., Gerardy-Schahn R.,
RA Bosch D.;
RT "Molecular cloning of two Arabidopsis UDP-galactose transporters by
RT complementation of a deficient Chinese hamster ovary cell line.";
RL Glycobiology 15:193-201(2005).
RN [7]
RP GENE FAMILY.
RX PubMed=25053812; DOI=10.1073/pnas.1406073111;
RA Rautengarten C., Ebert B., Moreno I., Temple H., Herter T., Link B.,
RA Donas-Cofre D., Moreno A., Saez-Aguayo S., Blanco F., Mortimer J.C.,
RA Schultink A., Reiter W.D., Dupree P., Pauly M., Heazlewood J.L.,
RA Scheller H.V., Orellana A.;
RT "The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter
RT family of Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:11563-11568(2014).
CC -!- FUNCTION: Sugar transporter involved in the transport of nucleotide-
CC sugars from cytoplasm into the Golgi and/or the endoplasmic reticulum.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. UDP-
CC galactose:UMP antiporter (TC 2.A.7.11) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09511.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB006705; BAB09511.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED97226.1; -; Genomic_DNA.
DR EMBL; AK175459; BAD43222.1; -; mRNA.
DR EMBL; AK175461; BAD43224.1; -; mRNA.
DR EMBL; BT011744; AAS49107.1; -; mRNA.
DR RefSeq; NP_200782.1; NM_125366.5.
DR AlphaFoldDB; Q6NMB6; -.
DR BioGRID; 21339; 7.
DR IntAct; Q6NMB6; 7.
DR STRING; 3702.AT5G59740.1; -.
DR PaxDb; Q6NMB6; -.
DR PRIDE; Q6NMB6; -.
DR ProteomicsDB; 228606; -.
DR EnsemblPlants; AT5G59740.1; AT5G59740.1; AT5G59740.
DR GeneID; 836095; -.
DR Gramene; AT5G59740.1; AT5G59740.1; AT5G59740.
DR KEGG; ath:AT5G59740; -.
DR Araport; AT5G59740; -.
DR TAIR; locus:2174289; AT5G59740.
DR eggNOG; KOG1581; Eukaryota.
DR HOGENOM; CLU_036019_3_0_1; -.
DR InParanoid; Q6NMB6; -.
DR OMA; CGAIGQV; -.
DR OrthoDB; 820879at2759; -.
DR PhylomeDB; Q6NMB6; -.
DR PRO; PR:Q6NMB6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q6NMB6; baseline and differential.
DR Genevisible; Q6NMB6; AT.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0046964; F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 2: Evidence at transcript level;
KW Antiport; Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..344
FT /note="UDP-galactose/UDP-glucose transporter 5B"
FT /id="PRO_0000415965"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 324..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 322
FT /note="N -> S (in Ref. 3; BAD43222/BAD43224)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 344 AA; 38218 MW; E60128F7F32805E3 CRC64;
MAEPELVNGG VKENKLWKGV FAVSGIMSTL VIYGVLQEKI MRVPYGVNKE FFKHSLFLVF
CNRLTTSAVS AGALLASKKV LDPVAPVYKY CLISVTNILT TTCQYEALKY VSFPVQTLAK
CAKMIPVMVW GTLIMQKKYK GFDYLVAFLV TLGCSVFILF PAGDDVSPYN KGRENTVWGV
SLMAGYLGFD GFTSTFQDKL FKGYNMEIHN QIFYTTLCSC VLSFTGLILQ GHLLPAVDFV
SLHRDCLLDI ALLSTVATAS QFFISYTIRT FGALTFAAIM TTRQLASIML SCIWFSHPLS
WEQCIGSVIV FGSLYAKNLL NNKKNSQTQP PPPELPQYEK VESS
