UTR7_ARATH
ID UTR7_ARATH Reviewed; 323 AA.
AC Q94B65; Q9SB76;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=UDP-galactose/UDP-glucose transporter 7 {ECO:0000303|PubMed:22933714};
DE Short=AtUTr7 {ECO:0000303|PubMed:22933714};
GN Name=UTR7 {ECO:0000303|PubMed:22933714};
GN OrderedLocusNames=At4g31600 {ECO:0000312|Araport:AT4G31600};
GN ORFNames=F28M20.210 {ECO:0000312|EMBL:CAA19763.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=15456736; DOI=10.1093/glycob/cwh159;
RA Bakker H., Routier F., Oelmann S., Jordi W., Lommen A., Gerardy-Schahn R.,
RA Bosch D.;
RT "Molecular cloning of two Arabidopsis UDP-galactose transporters by
RT complementation of a deficient Chinese hamster ovary cell line.";
RL Glycobiology 15:193-201(2005).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE,
RP AND TOPOLOGY.
RX PubMed=22933714; DOI=10.1093/mp/sss074;
RA Handford M., Rodriguez-Furlan C., Marchant L., Segura M., Gomez D.,
RA Alvarez-Buylla E., Xiong G.Y., Pauly M., Orellana A.;
RT "Arabidopsis thaliana AtUTr7 encodes a golgi-localized UDP-glucose/UDP-
RT galactose transporter that affects lateral root emergence.";
RL Mol. Plant 5:1263-1280(2012).
RN [6]
RP GENE FAMILY.
RX PubMed=25053812; DOI=10.1073/pnas.1406073111;
RA Rautengarten C., Ebert B., Moreno I., Temple H., Herter T., Link B.,
RA Donas-Cofre D., Moreno A., Saez-Aguayo S., Blanco F., Mortimer J.C.,
RA Schultink A., Reiter W.D., Dupree P., Pauly M., Heazlewood J.L.,
RA Scheller H.V., Orellana A.;
RT "The Golgi localized bifunctional UDP-rhamnose/UDP-galactose transporter
RT family of Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:11563-11568(2014).
CC -!- FUNCTION: Nucleotide-sugar transporter that transports UDP-glucose and
CC UDP-galactose. Plays a role in lateral root and root hair development.
CC {ECO:0000269|PubMed:22933714}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:22933714}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q94B65-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Widely expressed with highest expression in roots.
CC {ECO:0000269|PubMed:22933714}.
CC -!- DISRUPTION PHENOTYPE: Early proliferation of lateral roots as well as
CC distorted root hairs when cultivated at high sucrose concentrations.
CC {ECO:0000269|PubMed:22933714}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. UGnT (TC 2.A.7.15)
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA19763.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79878.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL031004; CAA19763.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161579; CAB79878.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85934.1; -; Genomic_DNA.
DR EMBL; AY042818; AAK68758.1; -; mRNA.
DR EMBL; AY064629; AAL47342.1; -; mRNA.
DR PIR; T05110; T05110.
DR RefSeq; NP_567879.1; NM_119309.4. [Q94B65-1]
DR AlphaFoldDB; Q94B65; -.
DR SMR; Q94B65; -.
DR IntAct; Q94B65; 2.
DR STRING; 3702.AT4G31600.1; -.
DR PaxDb; Q94B65; -.
DR PRIDE; Q94B65; -.
DR ProteomicsDB; 228666; -. [Q94B65-1]
DR EnsemblPlants; AT4G31600.1; AT4G31600.1; AT4G31600. [Q94B65-1]
DR GeneID; 829287; -.
DR Gramene; AT4G31600.1; AT4G31600.1; AT4G31600. [Q94B65-1]
DR KEGG; ath:AT4G31600; -.
DR Araport; AT4G31600; -.
DR TAIR; locus:2124819; AT4G31600.
DR eggNOG; KOG1444; Eukaryota.
DR HOGENOM; CLU_040726_2_1_1; -.
DR InParanoid; Q94B65; -.
DR OMA; VRGTKYM; -.
DR PhylomeDB; Q94B65; -.
DR PRO; PR:Q94B65; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q94B65; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IDA:TAIR.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0005460; F:UDP-glucose transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0048527; P:lateral root development; IMP:TAIR.
DR GO; GO:0080147; P:root hair cell development; IMP:TAIR.
DR GO; GO:0072334; P:UDP-galactose transmembrane transport; IDA:TAIR.
DR GO; GO:0015786; P:UDP-glucose transmembrane transport; IDA:TAIR.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..323
FT /note="UDP-galactose/UDP-glucose transporter 7"
FT /id="PRO_0000439529"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000303|PubMed:22933714"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..35
FT /note="Lumenal"
FT /evidence="ECO:0000303|PubMed:22933714"
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000303|PubMed:22933714"
FT TRANSMEM 79..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..101
FT /note="Lumenal"
FT /evidence="ECO:0000303|PubMed:22933714"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000303|PubMed:22933714"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154
FT /note="Lumenal"
FT /evidence="ECO:0000303|PubMed:22933714"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..186
FT /note="Cytoplasmic"
FT /evidence="ECO:0000303|PubMed:22933714"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..226
FT /note="Lumenal"
FT /evidence="ECO:0000303|PubMed:22933714"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..252
FT /note="Cytoplasmic"
FT /evidence="ECO:0000303|PubMed:22933714"
FT TRANSMEM 253..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..278
FT /note="Lumenal"
FT /evidence="ECO:0000303|PubMed:22933714"
FT TRANSMEM 279..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000303|PubMed:22933714"
SQ SEQUENCE 323 AA; 34625 MW; 6FEDD974D5F991B1 CRC64;
MEVQAEMEPT SSISLVAAVS YGIASMAMVF INKAVIMQYP HSMTVLTLQQ LATSLLIHFG
RRMGYTRAKG IDMATAKKLL PVSIFYNANV AFALASLKGV NIPMYIAIKR LTPLAVLISG
VLFGKGKPTT QVALSVLLTA AGCVIAALGD FSFDLFGYGL ALTSVFFQTM YLVLVEKSGA
EDGLSSIEIM FYNSFLSLPF LSILIIVTGE FPNSLSLLLA KCSYLPFLVI LILSLVMGIV
LNFTMFLCTI VNSALTTTIV GVLKGVGSTT LGFVLLGGVE VHALNVSGLV VNTAGGVWYS
YAKYRQKKAK PAKLMSDLEA HKK
