ID   UTS1_CARAU              Reviewed;         145 AA.
AC   Q9PTQ4;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=UI;
DE   Contains:
DE     RecName: Full=Urophysin;
DE   Contains:
DE     RecName: Full=Urotensin-1;
DE     AltName: Full=Urotensin I;
DE   Flags: Precursor;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=10603283; DOI=10.1006/gcen.1999.7386;
RA   Bernier N.J., Lin X., Peter R.E.;
RT   "Differential expression of corticotropin-releasing factor (CRF) and
RT   urotensin I precursor genes, and evidence of CRF gene expression regulated
RT   by cortisol in goldfish brain.";
RL   Gen. Comp. Endocrinol. 116:461-477(1999).
CC   -!- FUNCTION: Urotensin is found in the teleost caudal neurosecretory
CC       system. It has a suggested role in osmoregulation and as a
CC       corticotropin-releasing factor. The non-hormonal portion of this
CC       precursor may be a urotensin binding protein, urophysin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   EMBL; AF129115; AAF24136.1; -; mRNA.
DR   AlphaFoldDB; Q9PTQ4; -.
DR   SMR; Q9PTQ4; -.
DR   Ensembl; ENSCART00000075526; ENSCARP00000070783; ENSCARG00000032132.
DR   Ensembl; ENSCART00000091364; ENSCARP00000083677; ENSCARG00000040288.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR003620; Urocortin_CRF.
DR   PANTHER; PTHR15035; PTHR15035; 1.
DR   Pfam; PF00473; CRF; 1.
DR   PRINTS; PR01612; CRFFAMILY.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..100
FT                   /note="Urophysin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000006249"
FT   PEPTIDE         103..143
FT                   /note="Urotensin-1"
FT                   /id="PRO_0000006250"
FT   MOD_RES         143
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   145 AA;  16242 MW;  5836B3E41A062E71 CRC64;
     MKPVPLVLLI TSVLLTTHIP LSTCRPRDLS LVNSQLDDVL SNGAGDDAMS YLVGEKLLQY
     LQRNLGAQKA SGVLHLPHFP AAQLRSPHED SSLEELTEFS KRNDDPPISI DLTFHLLRNM
     IEMARNENQR EQAGLNRKYL DEVGK