ID   UTS1_CATCO              Reviewed;          41 AA.
AC   P01145;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Urotensin-1;
DE   AltName: Full=Urotensin I;
OS   Catostomus commersonii (White sucker) (Cyprinus commersonnii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Catostomoidei; Catostomidae; Catostomus.
OX   NCBI_TaxID=7971;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT VAL-41.
RX   PubMed=6981844; DOI=10.1126/science.6981844;
RA   Lederis K., Letter A., McMaster D., Moore G., Schlesinger D.;
RT   "Complete amino acid sequence of urotensin I, a hypotensive and
RT   corticotropin-releasing neuropeptide from Catostomus.";
RL   Science 218:162-164(1982).
RN   [2]
RP   PROTEIN SEQUENCE.
RX   PubMed=6313156; DOI=10.1139/o83-076;
RA   Lederis K., Letter A., McMaster D., Ichikawa T., McCannell K.L., Rivier J.,
RA   Rivier C., Vale W., Fryer J., Kobayashi Y.;
RT   "Isolation, analysis of structure, synthesis, and biological actions of
RT   urotensin I neuropeptides.";
RL   Can. J. Biochem. Cell Biol. 61:602-614(1983).
CC   -!- FUNCTION: Urotensin is found in the teleost caudal neurosecretory
CC       system. It has a suggested role in osmoregulation and as a
CC       corticotropin-releasing factor.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   PIR; A94267; UOCC1M.
DR   AlphaFoldDB; P01145; -.
DR   SMR; P01145; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR003620; Urocortin_CRF.
DR   PANTHER; PTHR15035; PTHR15035; 1.
DR   Pfam; PF00473; CRF; 1.
DR   PRINTS; PR01612; CRFFAMILY.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Secreted.
FT   CHAIN           1..41
FT                   /note="Urotensin-1"
FT                   /id="PRO_0000221024"
FT   MOD_RES         41
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:6981844"
SQ   SEQUENCE   41 AA;  4870 MW;  AEDB309BFB4A1971 CRC64;
     NDDPPISIDL TFHLLRNMIE MARIENEREQ AGLNRKYLDE V