ID   UTS1_CYPCA              Reviewed;         145 AA.
AC   P01146;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=UI;
DE   Contains:
DE     RecName: Full=Urophysin;
DE   Contains:
DE     RecName: Full=Urotensin-1;
DE     AltName: Full=Urotensin I;
DE   Flags: Precursor;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=3484550; DOI=10.1073/pnas.83.2.308;
RA   Ishida I., Ichikawa T., Deguchi T.;
RT   "Cloning and sequence analysis of cDNA encoding urotensin I precursor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:308-312(1986).
RN   [2]
RP   PROTEIN SEQUENCE OF 103-143, AND AMIDATION AT VAL-143.
RX   PubMed=6757895; DOI=10.1016/0196-9781(82)90028-6;
RA   Ichikawa T., McMaster D., Lederis K., Kobayashi H.;
RT   "Isolation and amino acid sequence of urotensin I, a vasoactive and ACTH-
RT   releasing neuropeptide, from the carp (Cyprinus carpio) urophysis.";
RL   Peptides 3:859-867(1982).
RN   [3]
RP   PROTEIN SEQUENCE OF 103-143, AND SYNTHESIS OF 103-143.
RX   PubMed=6313156; DOI=10.1139/o83-076;
RA   Lederis K., Letter A., McMaster D., Ichikawa T., McCannell K.L., Rivier J.,
RA   Rivier C., Vale W., Fryer J., Kobayashi Y.;
RT   "Isolation, analysis of structure, synthesis, and biological actions of
RT   urotensin I neuropeptides.";
RL   Can. J. Biochem. Cell Biol. 61:602-614(1983).
CC   -!- FUNCTION: Urotensin is found in the teleost caudal neurosecretory
CC       system. It has a suggested role in osmoregulation and as a
CC       corticotropin-releasing factor. The non-hormonal portion of this
CC       precursor may be a urotensin binding protein, urophysin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in the spinal cord and not in the brain,
CC       intestine, liver, or kidney. {ECO:0000269|PubMed:3484550}.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   EMBL; M11671; AAA49214.1; -; mRNA.
DR   PIR; A94096; UOCA1.
DR   AlphaFoldDB; P01146; -.
DR   SMR; P01146; -.
DR   Ensembl; ENSCCRT00000073214; ENSCCRP00000067558; ENSCCRG00000036421.
DR   Ensembl; ENSCCRT00010091556; ENSCCRP00010082532; ENSCCRG00010036070.
DR   Ensembl; ENSCCRT00020015221; ENSCCRP00020013804; ENSCCRG00020006786.
DR   GeneTree; ENSGT00940000154473; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR003620; Urocortin_CRF.
DR   PANTHER; PTHR15035; PTHR15035; 1.
DR   Pfam; PF00473; CRF; 1.
DR   PRINTS; PR01612; CRFFAMILY.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..100
FT                   /note="Urophysin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000006251"
FT   PEPTIDE         103..143
FT                   /note="Urotensin-1"
FT                   /id="PRO_0000006252"
FT   MOD_RES         143
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:6757895"
SQ   SEQUENCE   145 AA;  16250 MW;  4F16166A580E20FB CRC64;
     MKPVPLVLLL TSVLLTTHIP LSTCRPRDLS LMNSQLDDVL LNGAGDGAMS YLVGEKLLQY
     LQRNLGAQKA GGVLHLPHFP TAQLHSPHED NSLEELTEFS KRNDDPPISI DLTFHLLRNM
     IEMARNENQR EQAGLNRKYL DEVGK