ID   UTS1_PLAFE              Reviewed;          60 AA.
AC   P21624;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=UI;
DE   Contains:
DE     RecName: Full=Urophysin;
DE   Contains:
DE     RecName: Full=Urotensin-1;
DE     AltName: Full=Urotensin I;
DE   Flags: Precursor; Fragments;
OS   Platichthys flesus (European flounder) (Pleuronectes flesus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae;
OC   Platichthys.
OX   NCBI_TaxID=8260;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT VAL-60.
RC   TISSUE=Urophysis;
RX   PubMed=2284199; DOI=10.1016/0196-9781(90)90004-o;
RA   Conlon J.M., Arnold-Reed D.E., Balment R.J.;
RT   "Urotensin I and its N-terminal flanking peptide from the flounder,
RT   Platichthys flesus.";
RL   Peptides 11:895-895(1990).
CC   -!- FUNCTION: Urotensin is found in the teleost caudal neurosecretory
CC       system. It has a suggested role in osmoregulation and as a
CC       corticotropin-releasing factor. The non-hormonal portion of this
CC       precursor may be a urotensin binding protein, urophysin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   PIR; A43978; A43978.
DR   PIR; B43978; B43978.
DR   AlphaFoldDB; P21624; -.
DR   SMR; P21624; -.
DR   PRIDE; P21624; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   InterPro; IPR003620; Urocortin_CRF.
DR   PANTHER; PTHR15035; PTHR15035; 1.
DR   Pfam; PF00473; CRF; 1.
DR   PRINTS; PR01612; CRFFAMILY.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Secreted.
FT   CHAIN           <1..>19
FT                   /note="Urophysin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000006255"
FT   PEPTIDE         20..60
FT                   /note="Urotensin-1"
FT                   /id="PRO_0000006256"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         60
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:2284199"
FT   NON_CONS        19..20
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   60 AA;  6624 MW;  41AC32D397078AA8 CRC64;
     AAAAGDSAAS DLLGDNILRS EDPPMSIDLT FHMLRNMIHM AKMEGEREQA QINRNLLDEV