ID   UTS2B_DANRE             Reviewed;         125 AA.
AC   Q7ZZY8;
DT   03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Prepro-urotensin II-beta;
DE   Contains:
DE     RecName: Full=Urophysin beta;
DE   Contains:
DE     RecName: Full=Urotensin II-beta;
DE              Short=U-II-beta;
DE              Short=UII-beta;
DE   Flags: Precursor;
GN   Name=uts2b;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spinal cord;
RA   Tostivint H., Parmentier C., Mille M., Piblinger R., Taxi J., Lihrmann I.,
RA   Calas A., Vaudry H.;
RT   "Molecular cloning of the cDNA encoding prepro-urotensin II beta in
RT   zebrafish.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Urotensin is found in the teleost caudal neurosecretory
CC       system. It has a suggested role in osmoregulation and as a
CC       corticotropin-releasing factor (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR   EMBL; AY253851; AAP06756.1; -; mRNA.
DR   RefSeq; NP_991154.1; NM_205591.1.
DR   AlphaFoldDB; Q7ZZY8; -.
DR   STRING; 7955.ENSDARP00000006318; -.
DR   PaxDb; Q7ZZY8; -.
DR   Ensembl; ENSDART00000021916; ENSDARP00000006318; ENSDARG00000017340.
DR   GeneID; 402853; -.
DR   KEGG; dre:402853; -.
DR   CTD; 257313; -.
DR   ZFIN; ZDB-GENE-040630-10; uts2b.
DR   eggNOG; ENOG502SCRX; Eukaryota.
DR   GeneTree; ENSGT00510000049583; -.
DR   HOGENOM; CLU_1991855_0_0_1; -.
DR   InParanoid; Q7ZZY8; -.
DR   OMA; FGIRKQF; -.
DR   OrthoDB; 1506988at2759; -.
DR   PhylomeDB; Q7ZZY8; -.
DR   TreeFam; TF330799; -.
DR   Reactome; R-DRE-375276; Peptide ligand-binding receptors.
DR   Reactome; R-DRE-416476; G alpha (q) signalling events.
DR   PRO; PR:Q7ZZY8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 11.
DR   Bgee; ENSDARG00000017340; Expressed in spinal cord and 3 other tissues.
DR   ExpressionAtlas; Q7ZZY8; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR   InterPro; IPR001483; Urotensin_II.
DR   Pfam; PF02083; Urotensin_II; 1.
DR   PROSITE; PS00984; UROTENSIN_II; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..106
FT                   /note="Urophysin beta"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036332"
FT   PROPEP          109..111
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036333"
FT   PEPTIDE         114..125
FT                   /note="Urotensin II-beta"
FT                   /id="PRO_0000036334"
FT   DISULFID        119..124
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  13992 MW;  534D1EA910973B9A CRC64;
     MMWKLLLLFA LLLTVLEPLL GHPVVQSAEM SFGRPVVVEE EQALNPEELS FSEQAYLSHD
     AAGFGYPSLI SGDISSDGLR TAGFVPSQAV KEALLEKPLW SRFLGSRKQY HKRGSNTECF
     WKYCV