UTS2B_HUMAN
ID UTS2B_HUMAN Reviewed; 119 AA.
AC Q765I0; B3KQY8; D3DNW1; Q2M1Z2;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Urotensin-2B;
DE AltName: Full=Urotensin II-related peptide;
DE AltName: Full=Urotensin IIB;
DE Short=U-IIB;
DE Short=UIIB;
DE AltName: Full=Urotensin-2 domain-containing protein;
DE Flags: Precursor;
GN Name=UTS2B; Synonyms=URP, UTS2D;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ILE-21.
RC TISSUE=Brain;
RX PubMed=14550283; DOI=10.1016/j.bbrc.2003.09.102;
RA Sugo T., Murakami Y., Shimomura Y., Harada M., Abe M., Ishibashi Y.,
RA Kitada C., Miyajima N., Suzuki N., Mori M., Fujino M.;
RT "Identification of urotensin II-related peptide as the urotensin II-
RT immunoreactive molecule in the rat brain.";
RL Biochem. Biophys. Res. Commun. 310:860-868(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ILE-21.
RA Nothacker H.-P., Civelli O.;
RT "Characterization of a novel urotensin II precursor: urotensin II B
RT (U2B).";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-21.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potent vasoconstrictor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB116021; BAC98929.1; -; mRNA.
DR EMBL; AY321313; AAQ83883.1; -; mRNA.
DR EMBL; AK090630; BAG52200.1; -; mRNA.
DR EMBL; CH471052; EAW78091.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78092.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78093.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78094.1; -; Genomic_DNA.
DR EMBL; BC112166; AAI12167.1; -; mRNA.
DR CCDS; CCDS3300.1; -.
DR RefSeq; NP_937795.2; NM_198152.3.
DR RefSeq; XP_011510933.1; XM_011512631.1.
DR AlphaFoldDB; Q765I0; -.
DR BioGRID; 129211; 2.
DR IntAct; Q765I0; 1.
DR STRING; 9606.ENSP00000340526; -.
DR PhosphoSitePlus; Q765I0; -.
DR BioMuta; UTS2B; -.
DR DMDM; 212287929; -.
DR jPOST; Q765I0; -.
DR PaxDb; Q765I0; -.
DR PRIDE; Q765I0; -.
DR ProteomicsDB; 68658; -.
DR Antibodypedia; 19374; 123 antibodies from 17 providers.
DR DNASU; 257313; -.
DR Ensembl; ENST00000340524.10; ENSP00000340526.5; ENSG00000188958.10.
DR Ensembl; ENST00000427544.6; ENSP00000398761.2; ENSG00000188958.10.
DR GeneID; 257313; -.
DR KEGG; hsa:257313; -.
DR MANE-Select; ENST00000340524.10; ENSP00000340526.5; NM_198152.5; NP_937795.2.
DR UCSC; uc003fsu.4; human.
DR CTD; 257313; -.
DR DisGeNET; 257313; -.
DR GeneCards; UTS2B; -.
DR HGNC; HGNC:30894; UTS2B.
DR HPA; ENSG00000188958; Tissue enhanced (retina).
DR MIM; 618134; gene.
DR neXtProt; NX_Q765I0; -.
DR OpenTargets; ENSG00000188958; -.
DR PharmGKB; PA142670632; -.
DR VEuPathDB; HostDB:ENSG00000188958; -.
DR eggNOG; ENOG502S3JR; Eukaryota.
DR GeneTree; ENSGT00390000003511; -.
DR HOGENOM; CLU_2060777_0_0_1; -.
DR InParanoid; Q765I0; -.
DR OMA; PKKRACF; -.
DR PhylomeDB; Q765I0; -.
DR TreeFam; TF338338; -.
DR PathwayCommons; Q765I0; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR SignaLink; Q765I0; -.
DR BioGRID-ORCS; 257313; 10 hits in 1027 CRISPR screens.
DR ChiTaRS; UTS2B; human.
DR GenomeRNAi; 257313; -.
DR Pharos; Q765I0; Tbio.
DR PRO; PR:Q765I0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q765I0; protein.
DR Bgee; ENSG00000188958; Expressed in secondary oocyte and 92 other tissues.
DR ExpressionAtlas; Q765I0; baseline and differential.
DR Genevisible; Q765I0; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR GO; GO:0008217; P:regulation of blood pressure; IBA:GO_Central.
DR InterPro; IPR043255; U-IIB.
DR InterPro; IPR001483; Urotensin_II.
DR PANTHER; PTHR36876; PTHR36876; 1.
DR PROSITE; PS00984; UROTENSIN_II; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT PROPEP 29..109
FT /evidence="ECO:0000250"
FT /id="PRO_0000036357"
FT PEPTIDE 112..119
FT /note="Urotensin-2B"
FT /id="PRO_0000036358"
FT DISULFID 113..118
FT /evidence="ECO:0000250"
FT VARIANT 21
FT /note="S -> I (in dbSNP:rs6788319)"
FT /evidence="ECO:0000269|PubMed:14550283,
FT ECO:0000269|PubMed:14702039, ECO:0000269|Ref.2"
FT /id="VAR_044517"
SQ SEQUENCE 119 AA; 13749 MW; 389E27F6469DA596 CRC64;
MNKILSSTVC FGLLTLLSVL SFLQSVHGRP YLTQGNEIFP DKKYTNREEL LLALLNKNFD
FQRPFNTDLA LPNKLEELNQ LEKLKEQLVE EKDSETSYAV DGLFSSHPSK RACFWKYCV
