UTS2B_MOUSE
ID UTS2B_MOUSE Reviewed; 113 AA.
AC Q765I1;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Urotensin-2B;
DE AltName: Full=Urotensin II-related peptide;
DE AltName: Full=Urotensin IIB;
DE Short=U-IIB;
DE Short=UIIB;
DE AltName: Full=Urotensin-2 domain-containing protein;
DE Flags: Precursor;
GN Name=Uts2b; Synonyms=Urp, Uts2d;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=14550283; DOI=10.1016/j.bbrc.2003.09.102;
RA Sugo T., Murakami Y., Shimomura Y., Harada M., Abe M., Ishibashi Y.,
RA Kitada C., Miyajima N., Suzuki N., Mori M., Fujino M.;
RT "Identification of urotensin II-related peptide as the urotensin II-
RT immunoreactive molecule in the rat brain.";
RL Biochem. Biophys. Res. Commun. 310:860-868(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Nothacker H.-P., Civelli O.;
RT "Characterization of a novel urotensin II precursor: urotensin II B
RT (U2B).";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potent vasoconstrictor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR EMBL; AB116020; BAC98928.1; -; mRNA.
DR EMBL; AY321315; AAQ83885.1; -; mRNA.
DR CCDS; CCDS28091.1; -.
DR RefSeq; NP_937809.1; NM_198166.3.
DR AlphaFoldDB; Q765I1; -.
DR SMR; Q765I1; -.
DR STRING; 10090.ENSMUSP00000070840; -.
DR iPTMnet; Q765I1; -.
DR PhosphoSitePlus; Q765I1; -.
DR MaxQB; Q765I1; -.
DR PaxDb; Q765I1; -.
DR PRIDE; Q765I1; -.
DR Antibodypedia; 19374; 123 antibodies from 17 providers.
DR DNASU; 224065; -.
DR Ensembl; ENSMUST00000070531; ENSMUSP00000070840; ENSMUSG00000056423.
DR GeneID; 224065; -.
DR KEGG; mmu:224065; -.
DR UCSC; uc007yvm.1; mouse.
DR CTD; 257313; -.
DR MGI; MGI:2677064; Uts2b.
DR VEuPathDB; HostDB:ENSMUSG00000056423; -.
DR eggNOG; ENOG502S3JR; Eukaryota.
DR GeneTree; ENSGT00390000003511; -.
DR HOGENOM; CLU_2060777_0_0_1; -.
DR InParanoid; Q765I1; -.
DR OMA; DWIMEAK; -.
DR OrthoDB; 1555288at2759; -.
DR PhylomeDB; Q765I1; -.
DR TreeFam; TF338338; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 224065; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Uts2b; mouse.
DR PRO; PR:Q765I1; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q765I1; protein.
DR Bgee; ENSMUSG00000056423; Expressed in neural tube and 14 other tissues.
DR ExpressionAtlas; Q765I1; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR GO; GO:0008217; P:regulation of blood pressure; ISO:MGI.
DR InterPro; IPR043255; U-IIB.
DR InterPro; IPR001483; Urotensin_II.
DR PANTHER; PTHR36876; PTHR36876; 1.
DR PROSITE; PS00984; UROTENSIN_II; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT PROPEP 28..103
FT /evidence="ECO:0000250"
FT /id="PRO_0000036359"
FT PEPTIDE 106..113
FT /note="Urotensin-2B"
FT /id="PRO_0000036360"
FT DISULFID 107..112
FT /evidence="ECO:0000250"
SQ SEQUENCE 113 AA; 12821 MW; 70E97F53B9285E2C CRC64;
MKVFSTSLWC GLLTLLSVMN LFKSVRGRPH LSSGHELFPA KEHAAQEKLT RNPGLQRPFH
AGGDLPSKLE ELRQVKKLRD WIMEAKNTGL SNALDNLSSS HTKKRACFWK YCV
