UTS2B_RAT
ID UTS2B_RAT Reviewed; 118 AA.
AC Q765I2;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Urotensin-2B;
DE AltName: Full=Urotensin II-related peptide;
DE AltName: Full=Urotensin IIB;
DE Short=U-IIB;
DE Short=UIIB;
DE AltName: Full=Urotensin-2 domain-containing protein;
DE Flags: Precursor;
GN Name=Uts2b; Synonyms=Urp, Uts2d;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 111-118, FUNCTION, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=14550283; DOI=10.1016/j.bbrc.2003.09.102;
RA Sugo T., Murakami Y., Shimomura Y., Harada M., Abe M., Ishibashi Y.,
RA Kitada C., Miyajima N., Suzuki N., Mori M., Fujino M.;
RT "Identification of urotensin II-related peptide as the urotensin II-
RT immunoreactive molecule in the rat brain.";
RL Biochem. Biophys. Res. Commun. 310:860-868(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Nothacker H.-P., Civelli O.;
RT "Characterization of a novel urotensin II precursor: urotensin II B
RT (U2B).";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potent vasoconstrictor. {ECO:0000269|PubMed:14550283}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in a number of tissues includinf brain,
CC thymus, spleen, testis and spinal cord. {ECO:0000269|PubMed:14550283}.
CC -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR EMBL; AB116019; BAC98927.1; -; mRNA.
DR EMBL; AY321314; AAQ83884.1; -; mRNA.
DR RefSeq; NP_937766.1; NM_198133.2.
DR AlphaFoldDB; Q765I2; -.
DR SMR; Q765I2; -.
DR STRING; 10116.ENSRNOP00000039320; -.
DR PaxDb; Q765I2; -.
DR PRIDE; Q765I2; -.
DR Ensembl; ENSRNOT00000042650; ENSRNOP00000039320; ENSRNOG00000038512.
DR GeneID; 378939; -.
DR KEGG; rno:378939; -.
DR UCSC; RGD:727977; rat.
DR CTD; 257313; -.
DR RGD; 727977; Uts2b.
DR eggNOG; ENOG502S3JR; Eukaryota.
DR GeneTree; ENSGT00390000003511; -.
DR HOGENOM; CLU_2060777_0_0_1; -.
DR InParanoid; Q765I2; -.
DR OMA; PKKRACF; -.
DR OrthoDB; 1555288at2759; -.
DR PhylomeDB; Q765I2; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:Q765I2; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000038512; Expressed in cerebellum and 2 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IDA:RGD.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR GO; GO:0008217; P:regulation of blood pressure; IDA:RGD.
DR InterPro; IPR043255; U-IIB.
DR InterPro; IPR001483; Urotensin_II.
DR PANTHER; PTHR36876; PTHR36876; 1.
DR PROSITE; PS00984; UROTENSIN_II; 1.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT PROPEP 28..108
FT /id="PRO_0000036361"
FT PEPTIDE 111..118
FT /note="Urotensin-2B"
FT /id="PRO_0000036362"
FT DISULFID 112..117
FT /evidence="ECO:0000250"
SQ SEQUENCE 118 AA; 13341 MW; 824DC58F9E9B3877 CRC64;
MKFFSTSLCF GLLALLSVTT LLHSVRGRPH LSSGHELFPA EEHTTQEKLP LGLLIRNPGF
QRPAHAGVDL PSKVEELRQL KKLREWFMEA KSAEPSNALD KLSSSHPIKR ACFWKYCV
