ID   UTS2G_CYPCA             Reviewed;         125 AA.
AC   P06580;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Prepro-urotensin II-gamma;
DE   Contains:
DE     RecName: Full=Urophysin gamma;
DE   Contains:
DE     RecName: Full=Urotensin II-gamma;
DE              Short=U-II-gamma;
DE              Short=UII-gamma;
DE   Flags: Precursor;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2427672; DOI=10.1523/jneurosci.06-09-02730.1986;
RA   Ohsako S., Ishida I., Ichikawa T., Deguchi T.;
RT   "Cloning and sequence analysis of cDNAs encoding precursors of urotensin
RT   II-alpha and -gamma.";
RL   J. Neurosci. 6:2730-2735(1986).
RN   [2]
RP   PROTEIN SEQUENCE OF 114-125.
RA   Munekata E., Ohtaki T., Ichikawa T., McMaster D., Lederis K.;
RL   (In) Rich D.H., Gross E. (eds.);
RL   Proceedings of the 7th American peptide symposium, pp.69-72, Pierce
RL   Chemical Co., Rockford Il. (1981).
CC   -!- FUNCTION: Urotensin is found in the teleost caudal neurosecretory
CC       system. It has a suggested role in osmoregulation and as a
CC       corticotropin-releasing factor. The non-hormonal portion of this
CC       precursor may be a urotensin binding protein, urophysin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR   EMBL; M14088; AAA49216.1; -; mRNA.
DR   PIR; I50499; I50499.
DR   AlphaFoldDB; P06580; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR   InterPro; IPR001483; Urotensin_II.
DR   Pfam; PF02083; Urotensin_II; 1.
DR   PROSITE; PS00984; UROTENSIN_II; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT   CHAIN           22..106
FT                   /note="Urophysin gamma"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036338"
FT   PROPEP          109..111
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036339"
FT   PEPTIDE         114..125
FT                   /note="Urotensin II-gamma"
FT                   /id="PRO_0000036340"
FT   DISULFID        119..124
SQ   SEQUENCE   125 AA;  13866 MW;  E1587DCFC8CB674D CRC64;
     MMCNLLLSCS VLLLSCSHLL AHPVTDTADM TYSGPDSVEE AGGVNPDDFS VSDLNEHLQR
     AAVAGYSPLF SQENIKVPGQ IPKEALRELL LEKPYRLIPP RGLWGSRRQF RKRGGGADCF
     WKYCI