UTS2_HUMAN
ID UTS2_HUMAN Reviewed; 124 AA.
AC O95399; Q5H8X7; Q6UXF6; Q9UKP7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Urotensin-2;
DE AltName: Full=Urotensin II;
DE Short=U-II;
DE Short=UII;
DE Flags: Precursor;
GN Name=UTS2; ORFNames=UNQ525/PRO1068;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Spinal cord;
RX PubMed=9861051; DOI=10.1073/pnas.95.26.15803;
RA Coulouarn Y., Lihrmann I., Jegou S., Anouar Y., Tostivint H.,
RA Beauvillain J.-C., Conlon J.M., Bern H.A., Vaudry H.;
RT "Cloning of the cDNA encoding the urotensin II precursor in frog and human
RT reveals intense expression of the urotensin II gene in motoneurons of the
RT spinal cord.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:15803-15808(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=10499587; DOI=10.1038/45809;
RA Ames R.S., Sarau H.M., Chambers J.K., Willette R.N., Aiyar N.V.,
RA Romanic A.M., Louden C.S., Foley J.J., Sauermelch C.F., Coatney R.W.,
RA Ao Z., Disa J., Holmes S.D., Stadel J.M., Martin J.D., Liu W.-S.,
RA Glover G.I., Wilson S., McNulty D.E., Ellis C.E., Elshourbagy N.A.,
RA Shabon U., Trill J.J., Hay D.W.P., Ohlstein E.H., Bergsma D.J.,
RA Douglas S.A.;
RT "Human urotensin-II is a potent vasoconstrictor and agonist for the orphan
RT receptor GPR14.";
RL Nature 401:282-286(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT THR-12.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP PROTEIN SEQUENCE OF 21-35 (ISOFORM 1).
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- FUNCTION: Highly potent vasoconstrictor.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O95399-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O95399-2; Sequence=VSP_013638;
CC -!- TISSUE SPECIFICITY: Brain specific.
CC -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR EMBL; AF104118; AAD13070.1; -; mRNA.
DR EMBL; AF140630; AAD55577.1; -; mRNA.
DR EMBL; AY358375; AAQ88741.1; -; mRNA.
DR EMBL; Z98884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS90.1; -. [O95399-2]
DR CCDS; CCDS91.1; -. [O95399-1]
DR RefSeq; NP_006777.1; NM_006786.3. [O95399-1]
DR RefSeq; NP_068835.1; NM_021995.2. [O95399-2]
DR RefSeq; XP_011538839.1; XM_011540537.2. [O95399-2]
DR RefSeq; XP_011538840.1; XM_011540538.1. [O95399-1]
DR PDB; 6HVB; NMR; -; A=117-124.
DR PDB; 6HVC; NMR; -; A=117-124.
DR PDBsum; 6HVB; -.
DR PDBsum; 6HVC; -.
DR AlphaFoldDB; O95399; -.
DR SMR; O95399; -.
DR BioGRID; 116116; 11.
DR IntAct; O95399; 3.
DR BindingDB; O95399; -.
DR GlyGen; O95399; 1 site, 1 O-linked glycan (1 site).
DR BioMuta; UTS2; -.
DR EPD; O95399; -.
DR jPOST; O95399; -.
DR MassIVE; O95399; -.
DR MaxQB; O95399; -.
DR PeptideAtlas; O95399; -.
DR PRIDE; O95399; -.
DR ProteomicsDB; 50851; -. [O95399-1]
DR ProteomicsDB; 50852; -. [O95399-2]
DR Antibodypedia; 1351; 263 antibodies from 26 providers.
DR DNASU; 10911; -.
DR Ensembl; ENST00000054668.5; ENSP00000054668.5; ENSG00000049247.14. [O95399-2]
DR Ensembl; ENST00000361696.10; ENSP00000355163.5; ENSG00000049247.14. [O95399-1]
DR GeneID; 10911; -.
DR KEGG; hsa:10911; -.
DR MANE-Select; ENST00000361696.10; ENSP00000355163.5; NM_006786.4; NP_006777.1.
DR UCSC; uc001aor.4; human. [O95399-1]
DR CTD; 10911; -.
DR DisGeNET; 10911; -.
DR GeneCards; UTS2; -.
DR HGNC; HGNC:12636; UTS2.
DR HPA; ENSG00000049247; Tissue enriched (brain).
DR MIM; 604097; gene.
DR neXtProt; NX_O95399; -.
DR OpenTargets; ENSG00000049247; -.
DR PharmGKB; PA37261; -.
DR VEuPathDB; HostDB:ENSG00000049247; -.
DR GeneTree; ENSGT00510000049583; -.
DR HOGENOM; CLU_156959_0_0_1; -.
DR InParanoid; O95399; -.
DR OMA; IISFSCP; -.
DR OrthoDB; 1506988at2759; -.
DR PhylomeDB; O95399; -.
DR TreeFam; TF330799; -.
DR PathwayCommons; O95399; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR SignaLink; O95399; -.
DR BioGRID-ORCS; 10911; 17 hits in 1065 CRISPR screens.
DR ChiTaRS; UTS2; human.
DR GeneWiki; UTS2; -.
DR GenomeRNAi; 10911; -.
DR Pharos; O95399; Tbio.
DR PRO; PR:O95399; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O95399; protein.
DR Bgee; ENSG00000049247; Expressed in adrenal tissue and 124 other tissues.
DR ExpressionAtlas; O95399; baseline and differential.
DR Genevisible; O95399; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005179; F:hormone activity; TAS:ProtInc.
DR GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; TAS:ProtInc.
DR GO; GO:0006936; P:muscle contraction; TAS:ProtInc.
DR GO; GO:0008217; P:regulation of blood pressure; IBA:GO_Central.
DR InterPro; IPR001483; Urotensin_II.
DR Pfam; PF02083; Urotensin_II; 1.
DR PROSITE; PS00984; UROTENSIN_II; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cleavage on pair of basic residues;
KW Direct protein sequencing; Disulfide bond; Hormone; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..20
FT PROPEP 21..110
FT /id="PRO_0000036346"
FT PEPTIDE 114..124
FT /note="Urotensin-2"
FT /id="PRO_0000036347"
FT DISULFID 118..123
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..27
FT /note="MYKLASCCLLFIGFLNPLLSLPLLDSR -> METNVFHLMLCVTSARTHKST
FT SLCFGHFNSYPSLPLIHDLLL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10499587"
FT /id="VSP_013638"
FT VARIANT 12
FT /note="I -> T (in dbSNP:rs34305100)"
FT /evidence="ECO:0000269|PubMed:12975309"
FT /id="VAR_053734"
FT VARIANT 74
FT /note="S -> N (in dbSNP:rs2890565)"
FT /id="VAR_029313"
SQ SEQUENCE 124 AA; 14296 MW; C7A5FC7EFE00D312 CRC64;
MYKLASCCLL FIGFLNPLLS LPLLDSREIS FQLSAPHEDA RLTPEELERA SLLQILPEML
GAERGDILRK ADSSTNIFNP RGNLRKFQDF SGQDPNILLS HLLARIWKPY KKRETPDCFW
KYCV
