ID   UTS2_MACMU              Reviewed;         125 AA.
AC   Q8HYC2;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Urotensin-2;
DE   AltName: Full=Urotensin II;
DE            Short=U-II;
DE            Short=UII;
DE   Flags: Precursor;
GN   Name=UTS2;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11976263; DOI=10.1038/sj.bjp.0704671;
RA   Elshourbagy N.A., Douglas S.A., Shabon U., Harrison S., Duddy G.,
RA   Sechler J.L., Ao Z., Maleeff B.E., Naselsky D., Disa J., Aiyar N.V.;
RT   "Molecular and pharmacological characterization of genes encoding
RT   urotensin-II peptides and their cognate G-protein-coupled receptors from
RT   the mouse and monkey.";
RL   Br. J. Pharmacol. 136:9-22(2002).
CC   -!- FUNCTION: Highly potent vasoconstrictor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR   EMBL; AY065983; AAL55429.1; -; mRNA.
DR   RefSeq; NP_001028067.1; NM_001032895.1.
DR   AlphaFoldDB; Q8HYC2; -.
DR   STRING; 9544.ENSMMUP00000000838; -.
DR   BindingDB; Q8HYC2; -.
DR   Ensembl; ENSMMUT00000000900; ENSMMUP00000000838; ENSMMUG00000000625.
DR   GeneID; 574246; -.
DR   KEGG; mcc:574246; -.
DR   CTD; 10911; -.
DR   VEuPathDB; HostDB:ENSMMUG00000000625; -.
DR   VGNC; VGNC:78750; UTS2.
DR   eggNOG; ENOG502SCRX; Eukaryota.
DR   GeneTree; ENSGT00510000049583; -.
DR   HOGENOM; CLU_156959_0_0_1; -.
DR   InParanoid; Q8HYC2; -.
DR   OMA; IISFSCP; -.
DR   OrthoDB; 1506988at2759; -.
DR   TreeFam; TF330799; -.
DR   PRO; PR:Q8HYC2; -.
DR   Proteomes; UP000006718; Chromosome 1.
DR   Bgee; ENSMMUG00000000625; Expressed in spleen and 15 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR   GO; GO:0008217; P:regulation of blood pressure; IBA:GO_Central.
DR   InterPro; IPR001483; Urotensin_II.
DR   Pfam; PF02083; Urotensin_II; 1.
DR   PROSITE; PS00984; UROTENSIN_II; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..111
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000036348"
FT   PEPTIDE         115..125
FT                   /note="Urotensin-2"
FT                   /id="PRO_0000036349"
FT   DISULFID        119..124
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  14171 MW;  570EE0B0FC129410 CRC64;
     MYKLASCCLL FIGFLNPLFS LPLLDSGEVS LQLSAPHEDA PLTSEELERA SLLQILPEML
     LGAERGDSLR KADSSTNIFN PRGNLRKFQD FSGQDPDILL SHLLARIRKP YKKRETPDCF
     WKYCV