UTS2_MOUSE
ID UTS2_MOUSE Reviewed; 123 AA.
AC Q9QZQ3;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Urotensin-2;
DE AltName: Full=Urotensin II;
DE Short=U-II;
DE Short=UII;
DE Flags: Precursor;
GN Name=Uts2; Synonyms=Ucn2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spinal cord;
RX PubMed=10486557; DOI=10.1016/s0014-5793(99)01003-0;
RA Coulouarn Y., Jegou S., Tostivint H., Vaudry H., Lihrmann I.;
RT "Cloning, sequence analysis and tissue distribution of the mouse and rat
RT urotensin II precursors.";
RL FEBS Lett. 457:28-32(1999).
CC -!- FUNCTION: Highly potent vasoconstrictor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Brain specific. Predominantly expressed in
CC motoneurons of the brainstem and spinal cord.
CC -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR EMBL; AF172175; AAD55767.1; -; mRNA.
DR CCDS; CCDS18977.1; -.
DR RefSeq; NP_036040.1; NM_011910.2.
DR AlphaFoldDB; Q9QZQ3; -.
DR STRING; 10090.ENSMUSP00000030803; -.
DR BindingDB; Q9QZQ3; -.
DR PaxDb; Q9QZQ3; -.
DR PRIDE; Q9QZQ3; -.
DR Antibodypedia; 1351; 263 antibodies from 26 providers.
DR DNASU; 24111; -.
DR Ensembl; ENSMUST00000030803; ENSMUSP00000030803; ENSMUSG00000028963.
DR GeneID; 24111; -.
DR KEGG; mmu:24111; -.
DR UCSC; uc008vyd.1; mouse.
DR CTD; 10911; -.
DR MGI; MGI:1346329; Uts2.
DR VEuPathDB; HostDB:ENSMUSG00000028963; -.
DR eggNOG; ENOG502SCRX; Eukaryota.
DR GeneTree; ENSGT00510000049583; -.
DR HOGENOM; CLU_156959_0_0_1; -.
DR InParanoid; Q9QZQ3; -.
DR OMA; IISFSCP; -.
DR OrthoDB; 1506988at2759; -.
DR PhylomeDB; Q9QZQ3; -.
DR TreeFam; TF330799; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 24111; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q9QZQ3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9QZQ3; protein.
DR Bgee; ENSMUSG00000028963; Expressed in lumbar subsegment of spinal cord and 20 other tissues.
DR ExpressionAtlas; Q9QZQ3; baseline and differential.
DR Genevisible; Q9QZQ3; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0097746; P:blood vessel diameter maintenance; ISO:MGI.
DR GO; GO:0045776; P:negative regulation of blood pressure; ISO:MGI.
DR GO; GO:0003105; P:negative regulation of glomerular filtration; ISO:MGI.
DR GO; GO:0010459; P:negative regulation of heart rate; ISO:MGI.
DR GO; GO:0046676; P:negative regulation of insulin secretion; ISO:MGI.
DR GO; GO:0035814; P:negative regulation of renal sodium excretion; ISO:MGI.
DR GO; GO:0035811; P:negative regulation of urine volume; ISO:MGI.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISO:MGI.
DR GO; GO:0045597; P:positive regulation of cell differentiation; ISO:MGI.
DR GO; GO:0046005; P:positive regulation of circadian sleep/wake cycle, REM sleep; ISO:MGI.
DR GO; GO:0010841; P:positive regulation of circadian sleep/wake cycle, wakefulness; ISO:MGI.
DR GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0010763; P:positive regulation of fibroblast migration; ISO:MGI.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISO:MGI.
DR GO; GO:0010460; P:positive regulation of heart rate; ISO:MGI.
DR GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; ISO:MGI.
DR GO; GO:0008217; P:regulation of blood pressure; IBA:GO_Central.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0033574; P:response to testosterone; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR InterPro; IPR001483; Urotensin_II.
DR Pfam; PF02083; Urotensin_II; 1.
DR PROSITE; PS00984; UROTENSIN_II; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..104
FT /evidence="ECO:0000255"
FT /id="PRO_0000036350"
FT PROPEP 107..109
FT /evidence="ECO:0000255"
FT /id="PRO_0000036351"
FT PEPTIDE 110..123
FT /note="Urotensin-2"
FT /id="PRO_0000036352"
FT REGION 57..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 117..122
FT /evidence="ECO:0000250"
SQ SEQUENCE 123 AA; 13625 MW; F96486195137F7F4 CRC64;
MDRVPFCCLL FIGLLNPLLS LPVTDTGERT LQLPVLEEDA LRALEELERM ALLQTLRQTM
GTEAGESPGE AGPSTETPTP RGSMRKAFAG QNSNTVLSRL LARTRKQHKQ HGAAPECFWK
YCI
