ID   UTS2_PELRI              Reviewed;         127 AA.
AC   P33715; Q9PSX6;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Urotensin-2;
DE   AltName: Full=Urotensin II;
DE            Short=U-II;
DE            Short=UII;
DE   Flags: Precursor;
GN   Name=UTS2;
OS   Pelophylax ridibundus (Marsh frog) (Rana ridibunda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=8406;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9861051; DOI=10.1073/pnas.95.26.15803;
RA   Coulouarn Y., Lihrmann I., Jegou S., Anouar Y., Tostivint H.,
RA   Beauvillain J.-C., Conlon J.M., Bern H.A., Vaudry H.;
RT   "Cloning of the cDNA encoding the urotensin II precursor in frog and human
RT   reveals intense expression of the urotensin II gene in motoneurons of the
RT   spinal cord.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:15803-15808(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 115-127.
RC   TISSUE=Brain;
RX   PubMed=1445302; DOI=10.1016/0006-291x(92)91095-8;
RA   Conlon J.M., O'Harte F., Smith D.D., Tonon M.-C., Vaudry H.;
RT   "Isolation and primary structure of urotensin II from the brain of a
RT   tetrapod, the frog Rana ridibunda.";
RL   Biochem. Biophys. Res. Commun. 188:578-583(1992).
CC   -!- FUNCTION: Involved in smooth muscle stimulating and ion mobilizing
CC       activities. It has a suggested role as a corticotropin-releasing
CC       factor.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Central nervous system. Spinal cord.
CC   -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR   EMBL; AF104117; AAD13069.1; -; mRNA.
DR   PIR; PQ0445; PQ0445.
DR   AlphaFoldDB; P33715; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR   InterPro; IPR001483; Urotensin_II.
DR   Pfam; PF02083; Urotensin_II; 1.
DR   PROSITE; PS00984; UROTENSIN_II; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..111
FT                   /id="PRO_0000036344"
FT   PEPTIDE         115..127
FT                   /note="Urotensin-2"
FT                   /id="PRO_0000036345"
FT   DISULFID        121..126
SQ   SEQUENCE   127 AA;  14732 MW;  FC26BC90E00C082E CRC64;
     MSKLFFCCLI LAGSFCSFRS LPIIVPSKGS LRLSESALDF GDLKSWDDET RLLRNLPMFV
     DKEAERDAED IFSKEGFGLD AYNMDDKEEL FDKHPRISLL SRLQSKDRKQ FKKRAGNLSE
     CFWKYCV